Full-Genome Scan for Linkage in 50 Families Segregating the Bipolar Affective Disease Phenotype

A genome scan of ∼12-cM initial resolution was done on 50 of a set of 51 carefully ascertained unilineal multiplex families segregating the bipolar affective disorder phenotype. In addition to standard multipoint linkage analysis methods, a simultaneous-search algorithm was applied in an attempt to...

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Bibliographic Details
Published in:American journal of human genetics 2000-01, Vol.66 (1), p.205-215
Main Authors: Friddle, Carl, Koskela, Rebecca, Ranade, Koustubh, Hebert, Joan, Cargill, Michele, Clark, Chris D., McInnis, Melvin, Simpson, Sylvia, McMahon, Francis, Stine, O. Colin, Meyers, Deborah, Xu, Jianfeng, MacKinnon, Dean, Swift-Scanlan, Theresa, Jamison, Kay, Folstein, Susan, Daly, Mark, Kruglyak, Leonid, Marr, Thomas, DePaulo, J. Raymond, Botstein, David
Format: Article
Language:English
Subjects:
Adult and adolescent clinical studies
Behavioral genetics
Biological and medical sciences
Bipolar disorder
Bipolar Disorder - genetics
Bipolar disorders
Genome scan
Genome, Human
Human
Humans
Linkage
Lod Score
Manic depression
Medical genetics
Medical sciences
Mental and behavioral disorders
Models, Genetic
Mood disorders
Pedigree
Phenotype
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
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Summary:A genome scan of ∼12-cM initial resolution was done on 50 of a set of 51 carefully ascertained unilineal multiplex families segregating the bipolar affective disorder phenotype. In addition to standard multipoint linkage analysis methods, a simultaneous-search algorithm was applied in an attempt to surmount the problem of genetic heterogeneity. The results revealed no linkage across the genome. The results exclude monogenic models and make it unlikely that two genes account for the disease in this sample. These results support the conclusion that at least several hundred kindreds will be required in order to establish linkage of susceptibility loci to bipolar disorder in heterogeneous populations.
ISSN:0002-9297
1537-6605
DOI:10.1086/302697