Drug induced lymphocytic colitis

Three cases are presented of lymphocytic colitis with chronic diarrhoea concurrent with longterm use of Cyclo 3 Fort, a phlebotonic drug used in France. The histological and immunopathological features of lymphocytic colitis are described. We show that lymphocytic colitis is drug induced, particular...

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Bibliographic Details
Published in:Gut 1994-03, Vol.35 (3), p.426-428
Main Authors: Beaugerie, L, Luboinski, J, Brousse, N, Cosnes, J, Chatelet, F P, Gendre, J P, Le Quintrec, Y
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Biological and medical sciences
Chemical Sciences
Colitis - chemically induced
Colitis - immunology
Colitis - pathology
Colon - pathology
Diarrhea - chemically induced
Drug toxicity and drugs side effects treatment
Female
HLA-DR Antigens - analysis
Humans
Leukocyte Count
Medical sciences
Organic chemistry
Pharmacology. Drug treatments
Plant Extracts - adverse effects
Receptors, Interleukin-2 - analysis
Toxicity: digestive system
Vascular Diseases - drug therapy
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Summary:Three cases are presented of lymphocytic colitis with chronic diarrhoea concurrent with longterm use of Cyclo 3 Fort, a phlebotonic drug used in France. The histological and immunopathological features of lymphocytic colitis are described. We show that lymphocytic colitis is drug induced, particularly in one patient where the immunopathological features of mucosal immune cell activation were induced by drug rechallenge. It is concluded that lymphocytic colitis may be drug induced, secondary to a chronic activation of the mucosal immune system by one or several components of the drug.
ISSN:0017-5749
1468-3288
1458-3288
DOI:10.1136/gut.35.3.426