MHC class II (I-A) region control of the IgE antibody, repertoire to the ABA-1 allergen of the nematode Ascaris

ABA-1 is an approximately 14,000 molecular weight (MW) allergen which is among the most abundant proteins synthesized by the nematode parasite Ascaris. IgG and IgE responses to it are major histocompatibility complex (MHC)-restricted in rodents and have only been found to occur in rats of the RT1u h...

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Bibliographic Details
Published in:Immunology 1991-04, Vol.72 (4), p.577-579
Main Authors: KENNEDY, M. W, FRASER, E. M, CHRISTIE, J. F
Format: Article
Language:English
Subjects:
Allergens - immunology
Analysis of the immune response. Humoral and cellular immunity
Animals
Antibodies, Helminth - biosynthesis
Antibody production
Antigens, Helminth - immunology
Ascaris - immunology
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Fundamental immunology
H-2 Antigens - genetics
Haplotypes - immunology
Histocompatibility Antigens Class II - immunology
Immunobiology
Immunoglobulin E - biosynthesis
Immunoglobulin G - biosynthesis
Mice
Mice, Inbred Strains
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Summary:ABA-1 is an approximately 14,000 molecular weight (MW) allergen which is among the most abundant proteins synthesized by the nematode parasite Ascaris. IgG and IgE responses to it are major histocompatibility complex (MHC)-restricted in rodents and have only been found to occur in rats of the RT1u haplotype and mice of the H-2s haplotype. Humans infected with the parasite vary substantially in their immune response to the allergen, but the genetic basis for this unknown. H-2 recombinant mice were used to identify the region within the MHC controlling antibody responses to the allergen. IgG antibody to immunoaffinity purified ABA-1 was assayed by radio-immunoassay and IgE by passive cutaneous anaphylaxis. This showed that the restriction element is the I-A molecule and that there was some evidence for I-E modulation of the level of response.
ISSN:0019-2805
1365-2567