Effects of lysine vasopressin and glypressin on the fibrinolytic system in cirrhosis

In eight patients with cirrhosis of the liver and portal hypertension an intravenous infusion of lysine vasopressin induced a rapid increase in the plasma level of the fibrinolytic proenzyme plasminogen activator. In contrast, triglycyl lysine vasopressin (glypressin; GVP), in a dose known to lower...

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Bibliographic Details
Published in:Gut 1979-07, Vol.20 (7), p.565-567
Main Authors: Douglas, J G, Forrest, J A, Prowse, C V, Cash, J D, Finlayson, N D
Format: Article
Language:English
Subjects:
Aged
Female
Fibrinolysis - drug effects
Humans
Hypertension, Portal - blood
Hypertension, Portal - enzymology
Liver Cirrhosis - blood
Liver Cirrhosis - enzymology
Lypressin - analogs & derivatives
Lypressin - pharmacology
Male
Middle Aged
Plasminogen Activators - blood
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Summary:In eight patients with cirrhosis of the liver and portal hypertension an intravenous infusion of lysine vasopressin induced a rapid increase in the plasma level of the fibrinolytic proenzyme plasminogen activator. In contrast, triglycyl lysine vasopressin (glypressin; GVP), in a dose known to lower portal venous pressure, produced no fibrinolytic response. This lack of fibrinolytic response represents an advantage of GVP over lysine vasopressin in addition to its longer in vivo half-life and lower cardiotoxicity. Clinical trials of GVP in the treatment of bleeding oesophageal varices are needed.
ISSN:0017-5749
1468-3288
1458-3288
DOI:10.1136/gut.20.7.565