Lack of effect of oral magnesium on high blood pressure: a double blind study

Seventeen unselected patients with mild to moderate essential hypertension and whose average supine blood pressure after two months' observation with no treatment was 154/100 mm Hg were entered into a double blind randomised crossover study of one month's treatment with magnesium aspartate...

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Bibliographic Details
Published in:BMJ 1985-07, Vol.291 (6490), p.235-238
Main Authors: Cappuccio, F P, Markandu, N D, Beynon, G W, Shore, A C, Sampson, B, MacGregor, G A
Format: Article
Language:English
Subjects:
Adult
Aged
Aspartic Acid - therapeutic use
Blood plasma
Blood pressure
Calcium
Clinical Research
Clinical Trials as Topic
Diuretics
Double-Blind Method
Excretion
Female
Humans
Hypertension
Hypertension - drug therapy
Hypertension - metabolism
Magnesium
Magnesium - blood
Magnesium - urine
Male
Middle Aged
Placebos
Potassium
Random Allocation
Sodium
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Summary:Seventeen unselected patients with mild to moderate essential hypertension and whose average supine blood pressure after two months' observation with no treatment was 154/100 mm Hg were entered into a double blind randomised crossover study of one month's treatment with magnesium aspartate (15 mmol magnesium/day) and treatment with placebo for a further month. This preparation of magnesium was well tolerated and did not cause diarrhoea. Despite a significant increase in plasma magnesium concentration and a significant increase in urinary excretion of magnesium while taking magnesium aspartate there was no fall in blood pressure compared with either treatment with placebo or values before treatment. The results provide no evidence for a role of dietary magnesium in the regulation of high blood pressure and are contrary to recent speculations.
ISSN:0267-0623
0959-8138
1468-5833
DOI:10.1136/bmj.291.6490.235