Transmission Ratio Distortion in Offspring of Mouse Heterozygous Carriers of a (7.18) Robertsonian Translocation

Transmission ratio distortion (TRD) is defined as a significant departure from expected Mendelian ratios of inheritance of an allele or chromosome. TRD is observed among specific regions of the mouse and human genome and is frequently associated with chromosome rearrangements such as Robertsonian (R...

Full description

Saved in:
Bibliographic Details
Published in:Genetics (Austin) 2005-02, Vol.169 (2), p.843-848
Main Authors: Underkoffler, Lara A, Mitchell, Laura E, Abdulali, Zaki S, Collins, Joelle N, Oakey, Rebecca J
Format: Article
Language:English
Subjects:
Animals
Chromosome Segregation
Chromosomes
Crosses, Genetic
Errors
Female
Females
Genetics
Heterozygote
Investigations
Karyotyping
Male
Meiosis
Mice
Mice, Inbred C3H
Mice, Inbred C57BL
Mice, Inbred DBA
Mice, Inbred Strains
Rodents
Sex Characteristics
Sex Ratio
Translocation, Genetic
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Transmission ratio distortion (TRD) is defined as a significant departure from expected Mendelian ratios of inheritance of an allele or chromosome. TRD is observed among specific regions of the mouse and human genome and is frequently associated with chromosome rearrangements such as Robertsonian (Rb) chromosomes. We intercrossed mice heterozygous for a (7.18) Rb translocation and genotyped chromosomes 7 and 18 in 1812 individuals, 47% of which were informative for chromosome segregation. We substantiated previous findings that females were less likely than expected to transmit the Rb chromosome to their offspring. Surprisingly, however, we report that heterozygous males transmitted the Rb translocation chromosome significantly more frequently than the acrocentrics. The transmission of the Rb chromosome was not significantly influenced by either the sex of the Rb grandparent or the strain of the Rb.
ISSN:0016-6731
1943-2631
1943-2631
DOI:10.1534/genetics.104.032755