IgE- and IgE+Ag-mediated mast cell migration in an autocrine/paracrine fashion

Mast cells are the major effector cells for immediate hypersensitivity and chronic allergic reactions. These cells accumulate in mucosal tissues of allergic reactions, where immunoglobulin E (IgE) is produced locally. Here we provide evidence that, in addition to antigen that can attract IgE-bound m...

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Bibliographic Details
Published in:Blood 2005-04, Vol.105 (8), p.3222-3229
Main Authors: Kitaura, Jiro, Kinoshita, Tatsuya, Matsumoto, Masaaki, Chung, Shaun, Kawakami, Yuko, Leitges, Michael, Wu, Dianqing, Lowell, Clifford A., Kawakami, Toshiaki
Format: Article
Language:English
Subjects:
Allergic diseases
Animals
Antigens - immunology
Antigens - pharmacology
Autocrine Communication - immunology
Biological and medical sciences
Cell Movement - immunology
Chemokines - pharmacology
General aspects
Immunobiology
Immunoglobulin E - immunology
Immunoglobulin E - pharmacology
Immunopathology
Integrins - metabolism
Mast Cells - cytology
Mast Cells - immunology
Mast Cells - metabolism
Medical sciences
Mice
Mice, Mutant Strains
Paracrine Communication - immunology
Phosphatidylinositol 3-Kinases - metabolism
Receptors, G-Protein-Coupled - metabolism
Receptors, IgE - metabolism
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Summary:Mast cells are the major effector cells for immediate hypersensitivity and chronic allergic reactions. These cells accumulate in mucosal tissues of allergic reactions, where immunoglobulin E (IgE) is produced locally. Here we provide evidence that, in addition to antigen that can attract IgE-bound mast cells, the type of IgE molecules that efficiently activate mast cells can promote the migration of mast cells in the absence of antigen. IgE- and IgE+Ag-mediated migration involves an autocrine/paracrine secretion of soluble factors including adenosine, leukotriene B4, and several chemokines. Their secretion depends on 2 tyrosine kinases, Lyn and Syk, and they are agonists of G-protein-coupled receptors and signal through phosphatidylinositol 3-kinase γ, leading to mast cell migration. In mouse experiments, naive mast cells are attracted to IgE, and IgE-sensitized mast cells are attracted to antigen. Therefore, IgE and antigen are implicated in mast cell accumulation at allergic tissue sites with local high IgE levels. (Blood. 2005;105:3222-3229)
ISSN:0006-4971
1528-0020
DOI:10.1182/blood-2004-11-4205