Cytotoxic Effects of Singlet Oxygen

The toxic effects of gas-phase singlet oxygen,1O2, on the ciliated respiratory epithelium of hamster trachea have been demonstrated. Tracheal explants treated with1O2showed a dose-dependent decrease in cilia beating frequency and focal ciliostasis. A statistically significant decrease in ciliary act...

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Bibliographic Details
Published in:Environmental health perspectives 1987-12, Vol.76, p.199-203
Main Authors: Schiff, Leonard J., Eisenberg, Walter C., Dziuba, John, Taylor, Kevin, Moore, Steven J.
Format: Article
Language:English
Subjects:
Animals
Chemical hazards
Cilia
Cilia - drug effects
Cilia - physiology
Cricetinae
Cultural values
Environmental health
Epithelium
Epithelium - drug effects
Epithelium - physiology
Mesocricetus
Organ Culture Techniques
Oxygen
Oxygen - pharmacology
Respiratory mucosa
Singlet Oxygen
Trachea - drug effects
Trachea - physiology
Vapor phases
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Summary:The toxic effects of gas-phase singlet oxygen,1O2, on the ciliated respiratory epithelium of hamster trachea have been demonstrated. Tracheal explants treated with1O2showed a dose-dependent decrease in cilia beating frequency and focal ciliostasis. A statistically significant decrease in ciliary activity occurred at1O2concentrations as low as 154 ppb after a 2-hr exposure. Cytological alterations in the mucociliary epithelium were observed in explants exposed to 235 ppb1O2or greater. When cytotoxic effects were related to the time of exposure to1O2, maximum effects occurred after a 4-hr exposure. In vitro recovery studies indicate that ciliary activity returned to normal between 4 and 8 hr after exposure.
ISSN:0091-6765
1552-9924
DOI:10.1289/ehp.8776199