Passive transfer of immunity to Mycobacterium avium in susceptible and resistant strains of mice

SUMMARY Naturally susceptible mice (C57BL/6) infected with M. avium (strain Weybridge) developed a population of splenic T cells which, on transfer to syngeneic recipient mice, conferred significant protection against a subsequent challenge inoculum of M. avium. Similar T cells from naturally resist...

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Bibliographic Details
Published in:Clinical and experimental immunology 1990-07, Vol.81 (1), p.109-115
Main Authors: STOKES, R. W., COLLINS, F. M.
Format: Article
Language:English
Subjects:
Analysis of the immune response. Humoral and cellular immunity
Animals
Biological and medical sciences
Cross Reactions
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Immunity, Cellular
Immunity, Innate
Immunization, Passive
Immunobiology
Mice
Mice, Inbred A - immunology
Mice, Inbred C57BL - immunology
Mice, Inbred Strains - immunology
Mycobacterium avium
Mycobacterium avium - growth & development
Mycobacterium avium - immunology
Mycobacterium bovis - immunology
Mycobacterium Infections - immunology
Mycobacterium tuberculosis - immunology
Organs and cells involved in the immune response
protective T cells
resistant mice
Spleen - microbiology
susceptible mice
T-Lymphocytes - immunology
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Summary:SUMMARY Naturally susceptible mice (C57BL/6) infected with M. avium (strain Weybridge) developed a population of splenic T cells which, on transfer to syngeneic recipient mice, conferred significant protection against a subsequent challenge inoculum of M. avium. Similar T cells from naturally resistant mice (A/J) did not protect syngeneic recipient mice. Growth of M. avium in donor mice only occurred in the C57BL/6 strain. Replication of M. avium in donor mice was necessary for the development of protective T cells. High numbers of killed mycobacterium did not induce immune T cells. In addition. A/J mice inoculated with increasing numbers of viable M. avium (which still did not replicate) failed to develop protective T lymphocytes. Further studies indicated that no protective T cells were present in the M. avium‐infected A/J mouse, although evidence for non‐specific immunity in these mice was obtained. In addition, BCG (which grows progressively in A/J mice) stimulated a population of splenic T cells which protected recipient mice from subsequent infection with M. tuberculosis.
ISSN:0009-9104
1365-2249
DOI:10.1111/j.1365-2249.1990.tb05299.x