Conjugation to Gold Nanoparticles Enhances Polyethylenimine's Transfer of Plasmid DNA into Mammalian Cells

Branched polyethylenimine (PEI) chains with an average molecular mass of 2 kDa (PEI2) have been covalently attached to gold nanoparticles (GNPs), and the potency of the resulting PEI2-GNPs conjugates as vectors for the delivery of plasmid DNA into monkey kidney (COS-7) cells in the presence of serum...

Full description

Saved in:
Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2003-08, Vol.100 (16), p.9138-9143
Main Authors: Thomas, Mini, Klibanov, Alexander M.
Format: Article
Language:English
Subjects:
Animals
Biological Sciences
Biology
Cell culture techniques
Cell membranes
Cell Nucleus - metabolism
Chromogenic Compounds - pharmacology
COS Cells
Cytotoxicity
Deoxyribonucleic acid
DNA
DNA - metabolism
Galactosides - pharmacology
Gene therapy
Gene Transfer Techniques
Genetic Vectors
Gold - chemistry
Humans
Indoles - pharmacology
Microscopy, Electron
Models, Chemical
Nanoparticles
Nanotechnology
Plasmids
Plasmids - metabolism
Polyethyleneimine - chemistry
Ratios
Spectrophotometry
Teeth
Time Factors
Transfection
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!