Immunisation against varicella in end stage and pre-end stage renal failure

OBJECTIVES To investigate the seroconversion rate and duration of persistence of protective antibody titres after varicella immunisation in children with renal failure. DESIGN 32 children (25 end stage and 7 pre-end stage renal failure) were immunised using 2 × 2000 plaque forming unit doses of vari...

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Bibliographic Details
Published in:Archives of disease in childhood 2000-02, Vol.82 (2), p.141-143
Main Authors: Webb, Nicholas J A, Fitzpatrick, Margaret M, Hughes, David A, Brocklebank, Trevor J, Judd, Brian A, Lewis, Malcolm A, Postlethwaite, Robert J, Smith, Patricia A, Corbitt, Gerald
Format: Article
Language:English
Subjects:
At Risk Persons
Biological and medical sciences
Chicken pox
end stage kidney failure
Enzymes
General and Specialist Paediatrics
Hepatitis
Hospitals
immunisation
Immunization
Infections
Investigations
Medical sciences
Mortality
Nephrology. Urinary tract diseases
Nephropathies. Renovascular diseases. Renal failure
Persistence
Renal failure
renal transplantation
Transplantation
Transplants & implants
Vaccines
varicella
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Summary:OBJECTIVES To investigate the seroconversion rate and duration of persistence of protective antibody titres after varicella immunisation in children with renal failure. DESIGN 32 children (25 end stage and 7 pre-end stage renal failure) were immunised using 2 × 2000 plaque forming unit doses of varicella vaccine 3 months apart. Varicella antibody titres were measured by enzyme linked immunosorbent assay. RESULTS All children initially seroconverted after immunisation. At a mean follow up of 20.3 months, 23 of 28 had protective antibody titres, 4 children having died of unrelated causes. Two children required a third booster dose. 11 children underwent renal transplantation; 10 had protective titres at the time of transplantation and, at a mean of 23.4 months after immunisation, 6 currently have protective titres. Minor side effects occurred after 11 vaccine doses in 9 children. No child developed varicella, despite 10 clear episodes of exposure to the wild-type virus. CONCLUSIONS Varicella immunisation in children with end stage and pre-end stage renal failure results in a high rate of seroconversion and persistence of protective antibody titres. More widespread use of the vaccine before renal transplantation is recommended.
ISSN:0003-9888
1468-2044
DOI:10.1136/adc.82.2.141