Do hyperoxaemia and hypocapnia add to the risk of brain injury after intrapartum asphyxia?

Background: Episodes of hyperoxaemia and hypocapnia, which may contribute to brain injury, occur unintentionally in severely asphyxiated neonates in the first postnatal hours. Objective: To determine whether hyperoxaemia and/or hypocapnia during the first 2 hours of life add to the risk of brain inj...

Full description

Saved in:
Bibliographic Details
Published in:Archives of disease in childhood. Fetal and neonatal edition 2005-01, Vol.90 (1), p.F49-F52
Main Authors: Klinger, G, Beyene, J, Shah, P, Perlman, M
Format: Article
Language:English
Subjects:
Age
Analysis of Variance
asphyxia
Asphyxia Neonatorum - complications
Cerebral palsy
Cerebral Palsy - etiology
Cohort Studies
confidence interval
Developmental Disabilities - etiology
Female
Fio2
fraction of inspired oxygen
HIE
Humans
hyperoxaemia
Hyperoxia - complications
hypocapnia
Hypocapnia - complications
Hypoxia
Hypoxia-Ischemia, Brain - etiology
hypoxic ischaemic encephalopathy
Infant, Newborn
Infants
Male
neonatal intensive care unit
Neonates
NICU
odds ratio
Original
outcome
oxygen
Oxygen - blood
Oxygen Inhalation Therapy - adverse effects
Paco2
Pao2
partial arterial carbon dioxide pressure
partial arterial oxygen pressure
Partial Pressure
Patients
Prognosis
Respiration
Respiration, Artificial - methods
Retrospective Studies
Risk Factors
Statistical analysis
Studies
Traumatic brain injury
Variables
Ventilation
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background: Episodes of hyperoxaemia and hypocapnia, which may contribute to brain injury, occur unintentionally in severely asphyxiated neonates in the first postnatal hours. Objective: To determine whether hyperoxaemia and/or hypocapnia during the first 2 hours of life add to the risk of brain injury after intrapartum asphyxia. Methods: Retrospective cohort study in term infants with post-asphyxial hypoxic ischaemic encephalopathy (HIE) born between 1985 and 1995. Severe and moderate hyperoxaemia were defined as Pao2 >26.6 and Pao2 >13.3 kPa (200 and 100 mm Hg). Severe and moderate hypocapnia were defined as Paco2
ISSN:1359-2998
1468-2052
DOI:10.1136/adc.2003.048785