Macular circulation in patients with diabetes mellitus with and without arterial hypertension

• Published in: British journal of ophthalmology 2000-12, Vol.84 (12), p.1392-1396
• Main Authors: Arend, O, Rüffer, M, Remky, A
• Format: Article
• Language: English
• Subjects: Adult; Analysis of Variance; Biological and medical sciences; Blood Flow Velocity - physiology; Blood pressure; Blood Pressure - physiology; Capillaries - physiopathology; capillary density; Correlation analysis; Diabetes; diabetes mellitus; Diabetic retinopathy; Diabetic Retinopathy - complications; Diabetic Retinopathy - physiopathology; Female; Fluorescein Angiography; Humans; Hypertension; Hypertension - complications; Hypertension - physiopathology; Macula Lutea - blood supply; Male; Medical imaging; Medical sciences; microcirculation; Microcirculation - physiology; Middle Aged; Morphology; Ophthalmology; Original articles - Clinical science; Retinopathies; Studies
• ISSN: 0007-1161; 1468-2079
• DOI: 10.1136/bjo.84.12.1392

BACKGROUND Previous fluorescein angiographic studies have shown alterations in the macular microcirculation in patients with diabetes mellitus and arterial hypertension. In both diseases capillary blood velocity was reduced and capillary density decreased. These changes were more pronounced in diabetic patients. We have examined the influence of arterial hypertension in combination with diabetes mellitus. METHODS 62 patients with diabetes mellitus and arterial hypertension (group 1) were matched with patients with diabetes mellitus but without arterial hypertension (group 2, match criteria: ETDRS stage of retinopathy). In all subjects fluorescein angiograms were performed with a scanning laser ophthalmoscope. Macular capillary blood velocity (CBV), perifoveal intercapillary area (PIA), the coefficient of variation of both parameters, the area of the foveal avascular zone (FAZ), and the arteriovenous passage time (AVP) were assessed by digital image analysis. RESULTS Systolic and diastolic blood pressures were significantly increased in the patients with arterial hypertension (systolic p=0.0008; diastolic p=0.03). Neither dynamic measures (AVP: 1.64 (0.49) seconds (group 1), 1.72 (0.58) seconds (group 2); CBV: 1.98 (0.39) mm/s (group 1), 2.09 (0.43) mm/s (group 2)) nor morphological measures (PIA: 7985 (3137) μm2 (group 1), 8338 (3376) μm2(group 2); FAZ: 0.319 (0.206) mm2 (group 1), 0.363 (0.237) mm2 (group 2)) were significantly different between the two groups of diabetic patients. CONCLUSION Arterial hypertension did not result in more severe macular capillary dropout than diabetes without hypertension. This might be explained by the fact that most of the patients were being treated with antihypertensive drugs.