Management of orbital lymphangioma using intralesional injection of OK-432

AIM To treat orbital lymphangioma with an intralesional injection of OK-432 (group AStreptococcus pyogenes of human origin). METHOD A 14 year old boy had a right orbital cystic lymphangioma. The visual acuity in the eye was 20/28. In an initial treatment, 0.02 mg of OK-432, was injected into the tum...

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Bibliographic Details
Published in:British journal of ophthalmology 2000-06, Vol.84 (6), p.614-617
Main Authors: Suzuki, Yasuhito, Obana, Akira, Gohto, Yuko, Miki, Tokuhiko, Otuka, Hisasi, Inoue, Yuichi
Format: Article
Language:English
Subjects:
Adolescent
Antineoplastic Agents - therapeutic use
Follow-Up Studies
Humans
Injections, Intralesional
intralesional injection
Lymphangioma, Cystic - drug therapy
Lymphangioma, Cystic - pathology
Magnetic Resonance Imaging
Male
orbital lymphangioma
Orbital Neoplasms - drug therapy
Orbital Neoplasms - pathology
Original articles - Clinical science
Picibanil - therapeutic use
Streptococcus pyogenes
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Summary:AIM To treat orbital lymphangioma with an intralesional injection of OK-432 (group AStreptococcus pyogenes of human origin). METHOD A 14 year old boy had a right orbital cystic lymphangioma. The visual acuity in the eye was 20/28. In an initial treatment, 0.02 mg of OK-432, was injected into the tumour after aspiration of the fluid contents, but no effect was seen. The second treatment was performed with 0.04 mg of OK-432. RESULT 4 months later, the lesion had totally shrunk to fibrous tissue. The side effects were fever, a local inflammatory reaction lasting 3 days, and increased intraocular pressure, which was managed by draining the fluid contents. Visual acuity improved to 20/15, and the visual field defect and restriction of eye movement seen before treatment disappeared. No recurrence was noted 1 year after treatment. CONCLUSION An intralesional injection of OK-432 shrunk the lymphangioma without functional disturbance and scar in the facial skin. OK-432 may be useful for orbital lymphangioma, but further studies are still warranted to determine efficacy, complications, and the optimal dose for safe treatment.
ISSN:0007-1161
1468-2079
DOI:10.1136/bjo.84.6.614