Risk factor assessment of endoscopically removed malignant colorectal polyps

Background—Malignant colorectal polyps are defined as endoscopically removed polyps with cancerous tissue which has invaded the submucosa. Various histological criteria exist for managing these patients. Aims—To determine the significance of histological findings of patients with malignant polyps. M...

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Bibliographic Details
Published in:Gut 1998-11, Vol.43 (5), p.669-674
Main Authors: Netzer, P, Forster, C, Biral, R, Ruchti, C, Neuweiler, J, Stauffer, E, Schönegg, R, Maurer, C, Hüsler, J, Halter, F, Schmassmann, A
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Cell Transformation, Neoplastic
colon cancer
Colonic Polyps - pathology
Colonic Polyps - surgery
colonoscopy
Colorectal cancer
Confidence intervals
Endoscopy
Endoscopy - methods
Female
Histology
Hospitals
Humans
Intestinal Polyps - pathology
Intestinal Polyps - surgery
Lymphatic system
Male
malignant polyps
Medical sciences
Metastasis
Middle Aged
Mortality
Neoplasm Invasiveness
Pathology
polypectomy
Polyploidy
Precancerous Conditions - pathology
Prognosis
Proliferation and Neoplasia
Rectal Neoplasms - pathology
Rectal Neoplasms - surgery
Risk Factors
Software
Stomach, duodenum, intestine, rectum, anus
Surgery
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the digestive system
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Summary:Background—Malignant colorectal polyps are defined as endoscopically removed polyps with cancerous tissue which has invaded the submucosa. Various histological criteria exist for managing these patients. Aims—To determine the significance of histological findings of patients with malignant polyps. Methods—Five pathologists reviewed the specimens of 85 patients initially diagnosed with malignant polyps. High risk malignant polyps were defined as having one of the following: incomplete polypectomy, a margin not clearly cancer-free, lymphatic or venous invasion, or grade III carcinoma. Adverse outcome was defined as residual cancer in a resection specimen and local or metastatic recurrence in the follow up period (mean 67 months). Results—Malignant polyps were confirmed in 70 cases. In the 32 low risk malignant polyps, no adverse outcomes occurred; 16 (42%) of the 38 patients with high risk polyps had adverse outcomes (p
ISSN:0017-5749
1468-3288
1458-3288
DOI:10.1136/gut.43.5.669