Role of nitric oxide in intestinal water and electrolyte transport

Since Palmer et al and Ignarroet al showed that vascular endothelial cells could synthesise nitric oxide (NO), this soluble gas has emerged as an important mediator, messenger and regulator of cell function in a number of physiological systems and pathophysiological states. 1-4 The effect of NO on t...

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Bibliographic Details
Published in:Gut 1999-02, Vol.44 (2), p.143-147
Main Authors: MOURAD, F H, TURVILL, J L, FARTHING, M J G
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Biological Transport - physiology
Colon
Fundamental and applied biological sciences. Psychology
Humans
Intestinal Absorption - physiology
Intestine. Mesentery
Leading
Malabsorption Syndromes - physiopathology
Nitric oxide
Nitric Oxide - physiology
Rodents
Small intestine
Vertebrates: digestive system
Water-Electrolyte Balance - physiology
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Summary:Since Palmer et al and Ignarroet al showed that vascular endothelial cells could synthesise nitric oxide (NO), this soluble gas has emerged as an important mediator, messenger and regulator of cell function in a number of physiological systems and pathophysiological states. 1-4 The effect of NO on the intestinal epithelium, the local microcirculation, the enteric nervous system, and inflammatory cascades has implicated it as a potential mediator of intestinal water and electrolyte transport. 5 Data produced by different groups over the past few years have been contradictory, some showing NO as an absorbagogue and others as a secretagogue.
ISSN:0017-5749
1468-3288
1458-3288
DOI:10.1136/gut.44.2.143