Soluble CD86 protein in serum samples of patients with asthma

Background: Previous studies have reported that soluble (s) CD86 is involved in the initiation of the immune response. A study was undertaken to investigate the concentrations of sCD86 in serum samples from patients with bronchial asthma and to determine the cell origin of sCD86. Methods: Serum sCD8...

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Bibliographic Details
Published in:Thorax 2004-10, Vol.59 (10), p.870-875
Main Authors: Shi, H-Z, Xie, Z-F, Deng, J-M, Chen, Y-Q, Xiao, C-Q
Format: Article
Language:English
Subjects:
Acute Disease
Adult
Antigens
Antigens, CD - blood
Asthma
Asthma - blood
B-Lymphocytes - immunology
B7-2 Antigen
Biological and medical sciences
Blood
Chronic obstructive pulmonary disease, asthma
Cytokines
Enzyme-Linked Immunosorbent Assay
Female
Humans
Ligands
Lymphocytes
Male
Medical sciences
Membrane Glycoproteins - blood
Neutrophils
pathogenesis
Pneumology
soluble CD86
T cell receptors
T-Lymphocytes - immunology
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Summary:Background: Previous studies have reported that soluble (s) CD86 is involved in the initiation of the immune response. A study was undertaken to investigate the concentrations of sCD86 in serum samples from patients with bronchial asthma and to determine the cell origin of sCD86. Methods: Serum sCD86 concentrations were measured in 52 asthmatic subjects and 25 non-atopic normal volunteers using an enzyme linked immunosorbent assay, and the relationship of serum sCD86 concentrations to asthma severity and to total and differential white cell counts was analysed. Each type of white blood cell was purified and cultured in vitro to determine the cell origin of serum sCD86. Results: Serum samples from patients with an acute asthma exacerbation had much higher levels of sCD86 (585.4 (20.5) IU/ml) than those from stable asthmatics (479.6 (15.7) IU/ml, p
ISSN:0040-6376
1468-3296
DOI:10.1136/thx.2004.021840