Influence of prior pregnancies on disease course and cause of death in systemic sclerosis

Background: Microchimerism from fetal or maternal cells transferred during pregnancy has been implicated in the pathogenesis of systemic sclerosis (SSc). Objective: To determine whether a prior pregnancy influenced disease progression and cause of death in patients with SSc. Patients and methods: Th...

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Bibliographic Details
Published in:Annals of the rheumatic diseases 2002-04, Vol.61 (4), p.346-350
Main Authors: Artlett, C M, Rasheed, M, Russo-Stieglitz, K E, Sawaya, H H B, Jimenez, S A
Format: Article
Language:English
Subjects:
Abortion
Adult
Age
Age of Onset
Aged
Antibodies, Antinuclear - analysis
Biological and medical sciences
Births
Cause of Death
Cohort Studies
confidence interval
Cytokines
Development and progression
diffuse systemic sclerosis
Disease
Disease Progression
dSSc
Extended Report
Female
Fetuses
Graft versus host reaction
Health aspects
Humans
Hypotheses
limited systemic sclerosis
lSSc
lungs
major histocompatibility complex
Maternal-fetal exchange
Medical sciences
MHC
Middle Aged
mortality
never pregnant
odds ratio
Pathogenesis
Pregnancy
Pregnancy - immunology
Pregnancy - statistics & numerical data
Pregnant women
prior pregnancies
Reproductive History
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Scleroderma
Scleroderma (Disease)
Scleroderma, Systemic - immunology
Scleroderma, Systemic - mortality
SSc
Studies
Systemic scleroderma
systemic sclerosis
Womens health
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Description
Summary:Background: Microchimerism from fetal or maternal cells transferred during pregnancy has been implicated in the pathogenesis of systemic sclerosis (SSc). Objective: To determine whether a prior pregnancy influenced disease progression and cause of death in patients with SSc. Patients and methods: The patients comprised a retrospective study cohort of 111 women with SSc: 78 patients with prior pregnancies (PP) and 33 who were never pregnant (NP), followed up at Thomas Jefferson University. Differences in age at onset, disease subset, organ involvement, cause of death, and type of antinuclear autoantibodies were evaluated statistically, including regression analysis. Results: The age at onset of SSc in NP patients was 32.0 years compared with 45.7 years in patients with one or two prior pregnancies (p
ISSN:0003-4967
1468-2060
DOI:10.1136/ard.61.4.346