Juvenile temporal arteritis and activated protein C resistance

Juvenile temporal arteritis (JTA) is a rare benign vascular lesion limited to the branches of the external carotid artery, first recognised by Lie et al. 1 Histological features of JTA include vasculitis (without giant cells and granulomas), lymphocytes infiltrate, and fibrous intimal proliferation....

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Bibliographic Details
Published in:Annals of the rheumatic diseases 2004-02, Vol.63 (2), p.215-216
Main Authors: Granel, B, Serratrice, J, Ene, N, Morange, P E, Disdier, P, Weiller, P-J
Format: Article
Language:English
Subjects:
Activated Protein C Resistance - complications
Adult
Anti-Inflammatory Agents - therapeutic use
Aspirin - therapeutic use
Biological and medical sciences
Blood
Diseases of the osteoarticular system
Family medical history
giant cell arteritis
Giant Cell Arteritis - complications
Giant Cell Arteritis - drug therapy
Humans
juvenile temporal arteritis
Letter
Male
Medical sciences
Mutation
Pain
protein C resistance
Proteins
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Thrombosis
Ultrasonic imaging
vasculitis
Veins & arteries
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Summary:Juvenile temporal arteritis (JTA) is a rare benign vascular lesion limited to the branches of the external carotid artery, first recognised by Lie et al. 1 Histological features of JTA include vasculitis (without giant cells and granulomas), lymphocytes infiltrate, and fibrous intimal proliferation. 1 Despite frequent local arterial thrombosis associated with the lesion, no study on the coagulation pathway has been undertaken until now. The reported patients who were treated with steroids had systemic symptoms and an associated systemic vasculitis. 3 More recently, rapid regression of the temporal pain in a patient with JTA treated with non-steroidal anti-inflammatory drugs has been reported. 7 Differential diagnosis includes Kimura's disease (angiolymphoid proliferative disorder of soft tissues with eosinophilia and raised immunoglobulin E, occurring almost exclusively in oriental men), angiolymphoid hyperplasia with eosinophilia, 8 giant cell arteritis, panarteritis nodosa, Takayasu's arteritis, and isolated vasculitis of the vasa vasorum. 9 Histopathological analysis often discloses arterial thrombosis associated with non-giant cell, non-necrotising, and non-granulomatous vasculitis.
ISSN:0003-4967
1468-2060
DOI:10.1136/ard.2003.008227