Accuracy of quantitative magnetic resonance imaging in the detection of ex vivo focal cartilage defects

Background: No established, non-invasive diagnostic procedure for quantifying focal cartilage defects is currently available. Objective: To test the accuracy of quantitative magnetic resonance imaging (qMRI) for reliable determination of cartilage defect size in various compartments of the human kne...

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Bibliographic Details
Published in:Annals of the rheumatic diseases 2005-08, Vol.64 (8), p.1120-1125
Main Authors: Graichen, H, Al-Shamari, D, Hinterwimmer, S, von Eisenhart-Rothe, R, Vogl, T, Eckstein, F
Format: Article
Language:English
Subjects:
Accuracy
Biological and medical sciences
Cartilage, Articular - injuries
Cartilage, Articular - pathology
Defects
Extended Report
focal cartilage defects
Fractures
Humans
Image Processing, Computer-Assisted - methods
Imaging, Three-Dimensional
Injuries of the limb. Injuries of the spine
Joint surgery
Knee
Knee Injuries - pathology
Knee Joint - pathology
knee joints
magnetic resonance imaging
Magnetic Resonance Imaging - methods
Medical sciences
NMR
Nuclear magnetic resonance
osteoarthritis
Osteochondritis Dissecans - pathology
osteochondrosis dissecans
Patella - pathology
qMRI
quantitative magnetic resonance imaging
Traumas. Diseases due to physical agents
validation
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Summary:Background: No established, non-invasive diagnostic procedure for quantifying focal cartilage defects is currently available. Objective: To test the accuracy of quantitative magnetic resonance imaging (qMRI) for reliable determination of cartilage defect size in various compartments of the human knee. Methods: 24 tibial and patellar cartilage plates were harvested during knee arthroplasty. 74 cylindrical defects with diameters of 3, 5, and 8 mm were created with a punch. In 15 specimens (51 defects), the cartilage cylinders (inside the punch) were removed (approach 1), while in 9 specimens (23 defects) the surrounding tissue was removed mechanically and the cartilage cylinder was left in place (approach 2). All plates were imaged with a T1 weighted water excitation gradient echo sequence at a resolution of 1.5 mm×0.31 mm×0.31 mm. The defect size was computed from the image data after interactive segmentation and compared with the known dimensions of the cylinders. Results: Although there was a significant overestimation of the defect size by qMRI in 3 mm defects (mean (SD) +1.3 (0.58) mm = ±42%; p
ISSN:0003-4967
1468-2060
DOI:10.1136/ard.2004.029678