A syndrome of immune complex glomerulonephritis and ophthalmic abnormalities

Two sibs (one male and one female) suffering from a combination of immune complex glomerulonephritis and various ophthalmologic disorders are presented. The two cases belong to a family in which the parents are not related and seven sibs are affected, three females and a male with the combination, a...

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Bibliographic Details
Published in:Journal of medical genetics 1999-08, Vol.36 (8), p.641-644
Main Authors: Amirlak, Iradj, Sabnis, Sharda G, Al-Gazali, Lihadh, Abdulrazzaq, Yousef M
Format: Article
Language:English
Subjects:
Abdomen
Abnormalities, Multiple
Biological and medical sciences
Blindness
Cataracts
Child, Preschool
Complex syndromes
Eye Diseases - genetics
Eye Diseases - pathology
Eye movements
Families & family life
Female
Genes, Recessive
Glaucoma
Glomerulonephritis - genetics
Glomerulonephritis - immunology
Glomerulonephritis - pathology
HIV
Human immunodeficiency virus
Humans
Immune Complex Diseases - genetics
Immune Complex Diseases - pathology
immune complex glomerulonephritis
Intellectual disabilities
Kidney diseases
Laboratories
Light
Male
Medical genetics
Medical sciences
Microscopy
ophthalmic abnormalities
Orbits
Parents & parenting
Pedigree
Peritoneal dialysis
Proteins
Short Report
Syndrome
Urine
Viral infections
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Description
Summary:Two sibs (one male and one female) suffering from a combination of immune complex glomerulonephritis and various ophthalmologic disorders are presented. The two cases belong to a family in which the parents are not related and seven sibs are affected, three females and a male with the combination, and three males with severe ophthalmological changes and proteinuria. Clinically, case 2 had only ophthalmological manifestations but renal biopsy findings were similar to those of case 1, which could mean that all the others with eye abnormalities also had renal disease. Although there are several reports of combinations of eye and renal disorders, the sibs reported here do not fit into any of the known syndromes.
ISSN:0022-2593
1468-6244
DOI:10.1136/jmg.36.8.641