Role of incidental and/or cured intestinal parasitic infections on profile of CD4+ and CD8+ T cell subsets and activation status in HIV‐1 infected and uninfected adult Ethiopians

SUMMARY Intestinal parasitic infections have been suggested to cause persistent immune activation leading to an unbalanced immune state. Such a state has been proposed to be a major factor in the pathogenesis of AIDS in an African context. The present study investigated the effect of incidental para...

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Bibliographic Details
Published in:Clinical and experimental immunology 2003-04, Vol.132 (1), p.113-119
Main Authors: KASSU, A., TSEGAYE, A., WOLDAY, D., PETROS, B., AKLILU, M., SANDERS, E. J., FONTANET, A. L., VAN BAARLE, D., HAMANN, D., DE WIT, T. F. RINKE
Format: Article
Language:English
Subjects:
Adult
Case-Control Studies
CD4-Positive T-Lymphocytes - immunology
CD8-Positive T-Lymphocytes - immunology
Ethiopia
Female
Flow Cytometry
Follow-Up Studies
HIV Infections - complications
HIV Infections - immunology
HIV-1
Humans
immune activation
Intestinal Diseases, Parasitic - drug therapy
Intestinal Diseases, Parasitic - immunology
Intestinal Diseases, Parasitic - virology
intestinal parasites
Lymphocyte Activation
Lymphocyte Count
Male
Middle Aged
Original
Statistics, Nonparametric
T cell subsets
T-Lymphocyte Subsets - immunology
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Summary:SUMMARY Intestinal parasitic infections have been suggested to cause persistent immune activation leading to an unbalanced immune state. Such a state has been proposed to be a major factor in the pathogenesis of AIDS in an African context. The present study investigated the effect of incidental parasitic infection and treatment on the profile of T cell differentiation and activation markers on CD4+ and CD8+ T cells from HIV‐1 infected and uninfected adult Ethiopians. Cryopreserved PBMCs from 64 subjects (41 HIV‐negative and 23 HIV‐positive) with follow‐up visits at 6‐monthly intervals were used to compare the effect of incidental intestinal parasites and their treatment upon T cell subset profiles and activation status. The samples were stained with antibodies to various T cell differentiation and activation markers allowing naive, memory, effector, memory/effector, activated and resting CD4+ and CD8+ T cell subsets to be quantified by triple‐colour FACScan. Incidental intestinal parasitic infections resulted in a significant increase in memory CD4+ T cell numbers both in HIV‐negative and HIV‐positive subjects (P 
ISSN:0009-9104
1365-2249
DOI:10.1046/j.1365-2249.2003.02106.x