Loading…
Pleiotropic effects of CXC chemokines in gastric carcinoma: differences in CXCL8 and CXCL1 expression between diffuse and intestinal types of gastric carcinoma
SUMMARY CXC chemokines modulate host immunity, neovascularization, growth and invasive behaviour of tumours. Despite their relevance in tumour biology, chemokine expression in intestinal‐ and diffuse‐type gastric carcinoma, which exhibit a completely different growth pattern, has not been investigat...
Saved in:
| Published in: | Clinical and experimental immunology 2003-12, Vol.134 (3), p.508-515 |
|---|---|
| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c6245-f41ffbedf115c3e43efb29149919f65f1502998056d473984bf32599f503106f3 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c6245-f41ffbedf115c3e43efb29149919f65f1502998056d473984bf32599f503106f3 |
| container_end_page | 515 |
| container_issue | 3 |
| container_start_page | 508 |
| container_title | Clinical and experimental immunology |
| container_volume | 134 |
| creator | ECK, M. SCHMAUßER, B. SCHELLER, K. BRÄNdlein, S. MÜLLER‐HERMELINK, H. K. |
| description | SUMMARY
CXC chemokines modulate host immunity, neovascularization, growth and invasive behaviour of tumours. Despite their relevance in tumour biology, chemokine expression in intestinal‐ and diffuse‐type gastric carcinoma, which exhibit a completely different growth pattern, has not been investigated in detail. In this study, expression of the CXC chemokines CXCL8 [interleukin (IL)‐8], CXCL1 [growth‐related oncogene alpha (Groα)], CXCL9 [monokine induced by interferon (IFN)‐γ] and CXCL10 [IFN‐γ‐inducible protein‐10 (IP‐10)] and the corresponding chemokine receptors CXCR1–3 was investigated by immunohistochemistry in intestinal‐ and diffuse‐type gastric carcinoma. Tumour cells of all patients expressed CXCL8. CXCL8 expression was significantly stronger in tumour cells of diffuse‐ rather than intestinal‐type gastric carcinoma (P |
| doi_str_mv | 10.1111/j.1365-2249.2003.02305.x |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1808898</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>19236476</sourcerecordid><originalsourceid>FETCH-LOGICAL-c6245-f41ffbedf115c3e43efb29149919f65f1502998056d473984bf32599f503106f3</originalsourceid><addsrcrecordid>eNqNktuKUzEUhoMoTq2-ggRB71pz7o7ggJRRBwp6oeBdSNOVmdTdpCZ7O-3T-Kpmt2XGw4XmJius71-H8COEKZnSel6up5QrOWFM6CkjhE8J40ROd_fQ6DZxH40IIXqiKRFn6FEp6_pUSrGH6IwKxdlM6hH68bGFkLqctsFh8B5cV3DyeP5ljt01bNLXEKHgEPGVLV2ukLPZhZg29hVehSrIEN2RqJpFg21cHSKKYbfNUEpIES-huwGIB0Vf4ACF2EHpQrQt7vZbOLT9q8lj9MDbtsCT0z1Gn99efJq_nyw-vLucv1lMnGJCTryg3i9h5SmVjoPg4JdMU6E11V5JTyVhWjdEqpWYcd2IpedMau0l4ZQoz8fo_Fh32y83sHIQu2xbs81hY_PeJBvM75kYrs1V-m5oQ5pGN7XAi1OBnL71dTGzCcVB29oIqS9mRvlMcUX-CVLNuBKVHaNnf4Dr1Of6XQOjGk0oG6o1R8jlVEoGfzsyJWbwilmbwRJmsIQZvGIOXjG7Kn3668p3wpM5KvD8BNjibOuzjS6UO07yOisTlXt95G5CC_v_HsDMLy6HiP8EATXbaQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>196890120</pqid></control><display><type>article</type><title>Pleiotropic effects of CXC chemokines in gastric carcinoma: differences in CXCL8 and CXCL1 expression between diffuse and intestinal types of gastric carcinoma</title><source>PubMed Central</source><creator>ECK, M. ; SCHMAUßER, B. ; SCHELLER, K. ; BRÄNdlein, S. ; MÜLLER‐HERMELINK, H. K.</creator><creatorcontrib>ECK, M. ; SCHMAUßER, B. ; SCHELLER, K. ; BRÄNdlein, S. ; MÜLLER‐HERMELINK, H. K.</creatorcontrib><description>SUMMARY
CXC chemokines modulate host immunity, neovascularization, growth and invasive behaviour of tumours. Despite their relevance in tumour biology, chemokine expression in intestinal‐ and diffuse‐type gastric carcinoma, which exhibit a completely different growth pattern, has not been investigated in detail. In this study, expression of the CXC chemokines CXCL8 [interleukin (IL)‐8], CXCL1 [growth‐related oncogene alpha (Groα)], CXCL9 [monokine induced by interferon (IFN)‐γ] and CXCL10 [IFN‐γ‐inducible protein‐10 (IP‐10)] and the corresponding chemokine receptors CXCR1–3 was investigated by immunohistochemistry in intestinal‐ and diffuse‐type gastric carcinoma. Tumour cells of all patients expressed CXCL8. CXCL8 expression was significantly stronger in tumour cells of diffuse‐ rather than intestinal‐type gastric carcinoma (P < 0·01) as determined by a semiquantitative score. CXCL1 was expressed almost exclusively by diffuse‐ but not intestinal‐type carcinoma cells. The corresponding chemokine receptors, CXCR1 and CXCR2, were found on carcinoma cells. Furthermore, CXCL8 expression correlated with number of tumour vessels (P < 0·01), suggesting an angiogenetic function in gastric carcinoma not only in vitro but also in vivo. CXCL10 and CXCL9, attractants for T cells, were expressed by peritumorous macrophages in close proximity to IFN‐γ‐producing CXCR3‐positive T cells in both tumour types. These chemokines may attract gastric carcinoma‐infiltrating T cells via an IFN‐γ‐mediated pathway and enhance host immunity against the tumour. In gastric carcinoma a complex interplay between CXC‐chemokine signals derived from both tumour cells and tumour‐infiltrating immune cells may exhibit pleiotropic effects in tumour biology that go far beyond their originally described functions as leucocyte chemoattractants. Because CXCL8 and CXCL1, which are known to increase growth and invasive behaviour of malignant tumours, are significantly stronger expressed in diffuse‐ than intestinal‐type gastric carcinoma, one may speculate that these chemokines influence the different growth pattern of gastric carcinoma types.</description><identifier>ISSN: 0009-9104</identifier><identifier>EISSN: 1365-2249</identifier><identifier>DOI: 10.1111/j.1365-2249.2003.02305.x</identifier><identifier>PMID: 14632759</identifier><identifier>CODEN: CEXIAL</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Antigens, CD - analysis ; Antigens, CD34 - analysis ; Antigens, Differentiation, Myelomonocytic - analysis ; Biological and medical sciences ; Carcinoma - blood supply ; Carcinoma - immunology ; Carcinoma - pathology ; CD3 Complex - analysis ; Chemokine CXCL1 ; Chemokine CXCL10 ; Chemokine CXCL9 ; chemokine receptors ; Chemokines, CXC - analysis ; Clinical Studies ; CXC chemokines ; gastric carcinoma ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Immunohistochemistry - methods ; Intercellular Signaling Peptides and Proteins - analysis ; Interferon-gamma - analysis ; Interleukin-8 - analysis ; Lymphocytes, Tumor-Infiltrating - immunology ; Medical sciences ; Neovascularization, Pathologic ; Regression Analysis ; Stomach Neoplasms - blood supply ; Stomach Neoplasms - immunology ; Stomach Neoplasms - pathology ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Tumors</subject><ispartof>Clinical and experimental immunology, 2003-12, Vol.134 (3), p.508-515</ispartof><rights>2004 INIST-CNRS</rights><rights>Copyright Blackwell Scientific Publications Ltd. Dec 2003</rights><rights>2003 Blackwell Publishing Ltd 2003</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6245-f41ffbedf115c3e43efb29149919f65f1502998056d473984bf32599f503106f3</citedby><cites>FETCH-LOGICAL-c6245-f41ffbedf115c3e43efb29149919f65f1502998056d473984bf32599f503106f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1808898/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1808898/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15319224$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14632759$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ECK, M.</creatorcontrib><creatorcontrib>SCHMAUßER, B.</creatorcontrib><creatorcontrib>SCHELLER, K.</creatorcontrib><creatorcontrib>BRÄNdlein, S.</creatorcontrib><creatorcontrib>MÜLLER‐HERMELINK, H. K.</creatorcontrib><title>Pleiotropic effects of CXC chemokines in gastric carcinoma: differences in CXCL8 and CXCL1 expression between diffuse and intestinal types of gastric carcinoma</title><title>Clinical and experimental immunology</title><addtitle>Clin Exp Immunol</addtitle><description>SUMMARY
CXC chemokines modulate host immunity, neovascularization, growth and invasive behaviour of tumours. Despite their relevance in tumour biology, chemokine expression in intestinal‐ and diffuse‐type gastric carcinoma, which exhibit a completely different growth pattern, has not been investigated in detail. In this study, expression of the CXC chemokines CXCL8 [interleukin (IL)‐8], CXCL1 [growth‐related oncogene alpha (Groα)], CXCL9 [monokine induced by interferon (IFN)‐γ] and CXCL10 [IFN‐γ‐inducible protein‐10 (IP‐10)] and the corresponding chemokine receptors CXCR1–3 was investigated by immunohistochemistry in intestinal‐ and diffuse‐type gastric carcinoma. Tumour cells of all patients expressed CXCL8. CXCL8 expression was significantly stronger in tumour cells of diffuse‐ rather than intestinal‐type gastric carcinoma (P < 0·01) as determined by a semiquantitative score. CXCL1 was expressed almost exclusively by diffuse‐ but not intestinal‐type carcinoma cells. The corresponding chemokine receptors, CXCR1 and CXCR2, were found on carcinoma cells. Furthermore, CXCL8 expression correlated with number of tumour vessels (P < 0·01), suggesting an angiogenetic function in gastric carcinoma not only in vitro but also in vivo. CXCL10 and CXCL9, attractants for T cells, were expressed by peritumorous macrophages in close proximity to IFN‐γ‐producing CXCR3‐positive T cells in both tumour types. These chemokines may attract gastric carcinoma‐infiltrating T cells via an IFN‐γ‐mediated pathway and enhance host immunity against the tumour. In gastric carcinoma a complex interplay between CXC‐chemokine signals derived from both tumour cells and tumour‐infiltrating immune cells may exhibit pleiotropic effects in tumour biology that go far beyond their originally described functions as leucocyte chemoattractants. Because CXCL8 and CXCL1, which are known to increase growth and invasive behaviour of malignant tumours, are significantly stronger expressed in diffuse‐ than intestinal‐type gastric carcinoma, one may speculate that these chemokines influence the different growth pattern of gastric carcinoma types.</description><subject>Antigens, CD - analysis</subject><subject>Antigens, CD34 - analysis</subject><subject>Antigens, Differentiation, Myelomonocytic - analysis</subject><subject>Biological and medical sciences</subject><subject>Carcinoma - blood supply</subject><subject>Carcinoma - immunology</subject><subject>Carcinoma - pathology</subject><subject>CD3 Complex - analysis</subject><subject>Chemokine CXCL1</subject><subject>Chemokine CXCL10</subject><subject>Chemokine CXCL9</subject><subject>chemokine receptors</subject><subject>Chemokines, CXC - analysis</subject><subject>Clinical Studies</subject><subject>CXC chemokines</subject><subject>gastric carcinoma</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Immunohistochemistry - methods</subject><subject>Intercellular Signaling Peptides and Proteins - analysis</subject><subject>Interferon-gamma - analysis</subject><subject>Interleukin-8 - analysis</subject><subject>Lymphocytes, Tumor-Infiltrating - immunology</subject><subject>Medical sciences</subject><subject>Neovascularization, Pathologic</subject><subject>Regression Analysis</subject><subject>Stomach Neoplasms - blood supply</subject><subject>Stomach Neoplasms - immunology</subject><subject>Stomach Neoplasms - pathology</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Tumors</subject><issn>0009-9104</issn><issn>1365-2249</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><recordid>eNqNktuKUzEUhoMoTq2-ggRB71pz7o7ggJRRBwp6oeBdSNOVmdTdpCZ7O-3T-Kpmt2XGw4XmJius71-H8COEKZnSel6up5QrOWFM6CkjhE8J40ROd_fQ6DZxH40IIXqiKRFn6FEp6_pUSrGH6IwKxdlM6hH68bGFkLqctsFh8B5cV3DyeP5ljt01bNLXEKHgEPGVLV2ukLPZhZg29hVehSrIEN2RqJpFg21cHSKKYbfNUEpIES-huwGIB0Vf4ACF2EHpQrQt7vZbOLT9q8lj9MDbtsCT0z1Gn99efJq_nyw-vLucv1lMnGJCTryg3i9h5SmVjoPg4JdMU6E11V5JTyVhWjdEqpWYcd2IpedMau0l4ZQoz8fo_Fh32y83sHIQu2xbs81hY_PeJBvM75kYrs1V-m5oQ5pGN7XAi1OBnL71dTGzCcVB29oIqS9mRvlMcUX-CVLNuBKVHaNnf4Dr1Of6XQOjGk0oG6o1R8jlVEoGfzsyJWbwilmbwRJmsIQZvGIOXjG7Kn3668p3wpM5KvD8BNjibOuzjS6UO07yOisTlXt95G5CC_v_HsDMLy6HiP8EATXbaQ</recordid><startdate>200312</startdate><enddate>200312</enddate><creator>ECK, M.</creator><creator>SCHMAUßER, B.</creator><creator>SCHELLER, K.</creator><creator>BRÄNdlein, S.</creator><creator>MÜLLER‐HERMELINK, H. K.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><general>Oxford University Press</general><general>Blackwell Science Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>M7N</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>200312</creationdate><title>Pleiotropic effects of CXC chemokines in gastric carcinoma: differences in CXCL8 and CXCL1 expression between diffuse and intestinal types of gastric carcinoma</title><author>ECK, M. ; SCHMAUßER, B. ; SCHELLER, K. ; BRÄNdlein, S. ; MÜLLER‐HERMELINK, H. K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6245-f41ffbedf115c3e43efb29149919f65f1502998056d473984bf32599f503106f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Antigens, CD - analysis</topic><topic>Antigens, CD34 - analysis</topic><topic>Antigens, Differentiation, Myelomonocytic - analysis</topic><topic>Biological and medical sciences</topic><topic>Carcinoma - blood supply</topic><topic>Carcinoma - immunology</topic><topic>Carcinoma - pathology</topic><topic>CD3 Complex - analysis</topic><topic>Chemokine CXCL1</topic><topic>Chemokine CXCL10</topic><topic>Chemokine CXCL9</topic><topic>chemokine receptors</topic><topic>Chemokines, CXC - analysis</topic><topic>Clinical Studies</topic><topic>CXC chemokines</topic><topic>gastric carcinoma</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>Immunohistochemistry - methods</topic><topic>Intercellular Signaling Peptides and Proteins - analysis</topic><topic>Interferon-gamma - analysis</topic><topic>Interleukin-8 - analysis</topic><topic>Lymphocytes, Tumor-Infiltrating - immunology</topic><topic>Medical sciences</topic><topic>Neovascularization, Pathologic</topic><topic>Regression Analysis</topic><topic>Stomach Neoplasms - blood supply</topic><topic>Stomach Neoplasms - immunology</topic><topic>Stomach Neoplasms - pathology</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ECK, M.</creatorcontrib><creatorcontrib>SCHMAUßER, B.</creatorcontrib><creatorcontrib>SCHELLER, K.</creatorcontrib><creatorcontrib>BRÄNdlein, S.</creatorcontrib><creatorcontrib>MÜLLER‐HERMELINK, H. K.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Clinical and experimental immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ECK, M.</au><au>SCHMAUßER, B.</au><au>SCHELLER, K.</au><au>BRÄNdlein, S.</au><au>MÜLLER‐HERMELINK, H. K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pleiotropic effects of CXC chemokines in gastric carcinoma: differences in CXCL8 and CXCL1 expression between diffuse and intestinal types of gastric carcinoma</atitle><jtitle>Clinical and experimental immunology</jtitle><addtitle>Clin Exp Immunol</addtitle><date>2003-12</date><risdate>2003</risdate><volume>134</volume><issue>3</issue><spage>508</spage><epage>515</epage><pages>508-515</pages><issn>0009-9104</issn><eissn>1365-2249</eissn><coden>CEXIAL</coden><abstract>SUMMARY
CXC chemokines modulate host immunity, neovascularization, growth and invasive behaviour of tumours. Despite their relevance in tumour biology, chemokine expression in intestinal‐ and diffuse‐type gastric carcinoma, which exhibit a completely different growth pattern, has not been investigated in detail. In this study, expression of the CXC chemokines CXCL8 [interleukin (IL)‐8], CXCL1 [growth‐related oncogene alpha (Groα)], CXCL9 [monokine induced by interferon (IFN)‐γ] and CXCL10 [IFN‐γ‐inducible protein‐10 (IP‐10)] and the corresponding chemokine receptors CXCR1–3 was investigated by immunohistochemistry in intestinal‐ and diffuse‐type gastric carcinoma. Tumour cells of all patients expressed CXCL8. CXCL8 expression was significantly stronger in tumour cells of diffuse‐ rather than intestinal‐type gastric carcinoma (P < 0·01) as determined by a semiquantitative score. CXCL1 was expressed almost exclusively by diffuse‐ but not intestinal‐type carcinoma cells. The corresponding chemokine receptors, CXCR1 and CXCR2, were found on carcinoma cells. Furthermore, CXCL8 expression correlated with number of tumour vessels (P < 0·01), suggesting an angiogenetic function in gastric carcinoma not only in vitro but also in vivo. CXCL10 and CXCL9, attractants for T cells, were expressed by peritumorous macrophages in close proximity to IFN‐γ‐producing CXCR3‐positive T cells in both tumour types. These chemokines may attract gastric carcinoma‐infiltrating T cells via an IFN‐γ‐mediated pathway and enhance host immunity against the tumour. In gastric carcinoma a complex interplay between CXC‐chemokine signals derived from both tumour cells and tumour‐infiltrating immune cells may exhibit pleiotropic effects in tumour biology that go far beyond their originally described functions as leucocyte chemoattractants. Because CXCL8 and CXCL1, which are known to increase growth and invasive behaviour of malignant tumours, are significantly stronger expressed in diffuse‐ than intestinal‐type gastric carcinoma, one may speculate that these chemokines influence the different growth pattern of gastric carcinoma types.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>14632759</pmid><doi>10.1111/j.1365-2249.2003.02305.x</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0009-9104 |
| ispartof | Clinical and experimental immunology, 2003-12, Vol.134 (3), p.508-515 |
| issn | 0009-9104 1365-2249 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1808898 |
| source | PubMed Central |
| subjects | Antigens, CD - analysis Antigens, CD34 - analysis Antigens, Differentiation, Myelomonocytic - analysis Biological and medical sciences Carcinoma - blood supply Carcinoma - immunology Carcinoma - pathology CD3 Complex - analysis Chemokine CXCL1 Chemokine CXCL10 Chemokine CXCL9 chemokine receptors Chemokines, CXC - analysis Clinical Studies CXC chemokines gastric carcinoma Gastroenterology. Liver. Pancreas. Abdomen Humans Immunohistochemistry - methods Intercellular Signaling Peptides and Proteins - analysis Interferon-gamma - analysis Interleukin-8 - analysis Lymphocytes, Tumor-Infiltrating - immunology Medical sciences Neovascularization, Pathologic Regression Analysis Stomach Neoplasms - blood supply Stomach Neoplasms - immunology Stomach Neoplasms - pathology Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors |
| title | Pleiotropic effects of CXC chemokines in gastric carcinoma: differences in CXCL8 and CXCL1 expression between diffuse and intestinal types of gastric carcinoma |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T04%3A29%3A36IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Pleiotropic%20effects%20of%20CXC%20chemokines%20in%20gastric%20carcinoma:%20differences%20in%20CXCL8%20and%20CXCL1%20expression%20between%20diffuse%20and%20intestinal%20types%20of%20gastric%20carcinoma&rft.jtitle=Clinical%20and%20experimental%20immunology&rft.au=ECK,%20M.&rft.date=2003-12&rft.volume=134&rft.issue=3&rft.spage=508&rft.epage=515&rft.pages=508-515&rft.issn=0009-9104&rft.eissn=1365-2249&rft.coden=CEXIAL&rft_id=info:doi/10.1111/j.1365-2249.2003.02305.x&rft_dat=%3Cproquest_pubme%3E19236476%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c6245-f41ffbedf115c3e43efb29149919f65f1502998056d473984bf32599f503106f3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=196890120&rft_id=info:pmid/14632759&rfr_iscdi=true |