Fluvastatin treatment inhibits leucocyte adhesion and extravasation in models of complement‐mediated acute inflammation

SUMMARY Complement activation plays a relevant role in the development of tissue damage under inflammatory conditions, and clinical and experimental observations emphasize its contribution to inflammatory vasculitides. Statins have recently been shown to reduce cardiovascular morbidity independently...

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Bibliographic Details
Published in:Clinical and experimental immunology 2004-02, Vol.135 (2), p.186-193
Main Authors: FISCHETTI, F., CARRETTA, R., BOROTTO, G., DURIGUTTO, P., BULLA, R., MERONI, P. L., TEDESCO, F.
Format: Article
Language:English
Subjects:
Administration, Oral
Animal Studies
Animals
Anti-Inflammatory Agents - administration & dosage
Biological and medical sciences
Cell Adhesion - immunology
Chemotaxis, Leukocyte - immunology
complement
Complement Activation - immunology
Disease Models, Animal
Endothelium, Vascular - immunology
Fatty Acids, Monounsaturated - administration & dosage
Fluvastatin
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Immunopathology
Indoles - administration & dosage
leucocytes
Leukocytes - drug effects
Leukocytes - immunology
Lipids - blood
Male
Medical sciences
Microscopy, Video - methods
Neutrophils - immunology
Peritoneal Cavity
Peritonitis - immunology
rat
Rats
Rats, Wistar
videomicroscopy
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Summary:SUMMARY Complement activation plays a relevant role in the development of tissue damage under inflammatory conditions, and clinical and experimental observations emphasize its contribution to inflammatory vasculitides. Statins have recently been shown to reduce cardiovascular morbidity independently of plasma cholesterol lowering and in vitro studies support a direct anti‐inflammatory action of these drugs. The aim of this study was to verify the in vivo effect of fluvastatin on complement‐mediated acute peritoneal inflammation. The effect of oral treatment with fluvastatin was investigated in normo‐cholesterolaemic rats that received intraperitoneal injection of either yeast‐activated rat serum (Y‐act RS) or lipopolysaccharide to induce peritoneal inflammation monitored by the number of PMN recruited in peritoneal fluid washes. In addition, vascular adherence and extravasation of leucocytes were evaluated by direct videomicroscopy examination on mesentery postcapillary venules topically exposed to Y‐act RS. The number of PMN in the peritoneal washes of rats treated with fluvastatin was 38% lower than that of untreated animals (P 
ISSN:0009-9104
1365-2249
DOI:10.1111/j.1365-2249.2003.02358.x