Plasma inflammatory cytokines and chemokines in severe acute respiratory syndrome

SUMMARY Severe acute respiratory syndrome (SARS) is a recently emerged infectious disease caused by a novel coronavirus, but its immunopathological mechanisms have not yet been fully elucidated. We investigated changes in plasma T helper (Th) cell cytokines, inflammatory cytokines and chemokines in...

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Bibliographic Details
Published in:Clinical and experimental immunology 2004-04, Vol.136 (1), p.95-103
Main Authors: WONG, C. K., LAM, C. W. K., WU, A. K. L., IP, W. K., LEE, N. L. S., CHAN, I. H. S., LIT, L. C. W., HUI, D. S. C., CHAN, M. H. M., CHUNG, S. S. C., SUNG, J. J. Y.
Format: Article
Language:English
Subjects:
Adult
Anti-Inflammatory Agents - therapeutic use
Biological and medical sciences
Biomarkers - blood
chemokines
Chemokines - blood
Clinical Studies
cytokines
Cytokines - blood
Female
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Glucocorticoids - therapeutic use
Humans
Immunopathology
inflammation
Male
Medical sciences
Methylprednisolone - therapeutic use
Middle Aged
Prospective Studies
severe acute respiratory syndrome (SARS)
Severe Acute Respiratory Syndrome - blood
Severe Acute Respiratory Syndrome - drug therapy
T-Lymphocytes, Helper-Inducer - immunology
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Summary:SUMMARY Severe acute respiratory syndrome (SARS) is a recently emerged infectious disease caused by a novel coronavirus, but its immunopathological mechanisms have not yet been fully elucidated. We investigated changes in plasma T helper (Th) cell cytokines, inflammatory cytokines and chemokines in 20 patients diagnosed with SARS. Cytokine profile of SARS patients showed marked elevation of Th1 cytokine interferon (IFN)‐γ, inflammatory cytokines interleukin (IL)‐1, IL‐6 and IL‐12 for at least 2 weeks after disease onset, but there was no significant elevation of inflammatory cytokine tumour necrosis factor (TNF)‐α, anti‐inflammatory cytokine IL‐10, Th1 cytokine IL‐2 and Th2 cytokine IL‐4. The chemokine profile demonstrated significant elevation of neutrophil chemokine IL‐8, monocyte chemoattractant protein‐1 (MCP‐1), and Th1 chemokine IFN‐γ‐inducible protein‐10 (IP‐10). Corticosteroid reduced significantly IL‐8, MCP‐1 and IP‐10 concentrations from 5 to 8 days after treatment (all P 
ISSN:0009-9104
1365-2249
DOI:10.1111/j.1365-2249.2004.02415.x