Diagnostic accuracy of core biopsy for ductal carcinoma in situ and its implications for surgical practice

Background: Core biopsy is considered to be a highly accurate method of gaining a preoperative histological diagnosis of breast cancer. Ductal carcinoma in situ (DCIS) is often impalpable and is a more subtle form of breast cancer. Aim: To investigate the accuracy of core biopsy in the diagnosis of...

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Bibliographic Details
Published in:Journal of clinical pathology 2006-07, Vol.59 (7), p.740-743
Main Authors: Dillon, M F, Quinn, C M, McDermott, E W, O’Doherty, A, O’Higgins, N, Hill, A D K
Format: Article
Language:English
Subjects:
Accuracy
AIEP
atypical intraductal epithelial proliferation
Biological and medical sciences
Biopsy
Biopsy - methods
Breast - pathology
Breast cancer
Breast Neoplasms - diagnostic imaging
Breast Neoplasms - pathology
Breast Neoplasms - surgery
Calcification
Carcinoma, Intraductal, Noninfiltrating - diagnostic imaging
Carcinoma, Intraductal, Noninfiltrating - pathology
Carcinoma, Intraductal, Noninfiltrating - surgery
DCIS
ductal carcinoma in situ
Female
Histology
Humans
Investigative techniques, diagnostic techniques (general aspects)
Mammography
Mass Screening
Medical sciences
Medical screening
Middle Aged
Neoplasm Invasiveness
Original
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Preoperative Care - methods
Reoperation
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Summary:Background: Core biopsy is considered to be a highly accurate method of gaining a preoperative histological diagnosis of breast cancer. Ductal carcinoma in situ (DCIS) is often impalpable and is a more subtle form of breast cancer. Aim: To investigate the accuracy of core biopsy in the diagnosis of cancer in patients with DCIS. Methods: All patients who had invasive cancer (n = 959) or DCIS (n = 92) that was confirmed by excision between 1999 and 2004 were identified. The diagnostic methods, histology of the core biopsy specimen and excision histology were reviewed in detail. Results: Core biopsy was attempted in 88% (81/92) of patients with DCIS and in 91% (874/959) of those with invasive disease. Of those patients who underwent core biopsy, a diagnosis of carcinoma on the initial core was made in 65% (53/81) of patients with DCIS compared with 92% (800/874) of patients with invasive disease (p
ISSN:0021-9746
1472-4146
DOI:10.1136/jcp.2005.034330