Absence of an interaction between iron and mycophenolate mofetil absorption

Aim To determine whether concomitant iron affects the absorption of mycophenolate mofetil. Methods An open‐label, single centre, randomized, crossover trial was conducted in 16 healthy males. Fasting subjects received mycophenolate mofetil alone (treatment A) or co‐administered with iron (treatment...

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Published in:British journal of clinical pharmacology 2006-10, Vol.62 (4), p.492-495
Main Authors: Ducray, Patricia Sanwald, Banken, Ludger, Gerber, Marianne, Boutouyrie, Bruno, Zandt, Hagen
Format: Article
Language:English
Subjects:
absorption
Adult
Cross-Over Studies
Drug Interactions
Ferrous Compounds - administration & dosage
Ferrous Compounds - adverse effects
Humans
Immunosuppressive Agents - administration & dosage
Immunosuppressive Agents - pharmacokinetics
Iron
iron ion
Male
mycophenolate mofetil
Mycophenolic Acid - administration & dosage
Mycophenolic Acid - analogs & derivatives
Mycophenolic Acid - pharmacokinetics
Original
pharmacokinetics
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Summary:Aim To determine whether concomitant iron affects the absorption of mycophenolate mofetil. Methods An open‐label, single centre, randomized, crossover trial was conducted in 16 healthy males. Fasting subjects received mycophenolate mofetil alone (treatment A) or co‐administered with iron (treatment B). Results The mycophenolic acid AUC(0,24 h) for treatments A and B were 42.5 ± 10.5 and 44.7 ± 12.4 µg ml−1 h, respectively. anova modelling showed the relative bioavailability of mycophenolate mofetil to be similar for the two treatments (90% confidence interval 0.92, 1.19). Conclusions There was no interaction between mycophenolate mofetil and iron supplements administered concomitantly to healthy fasting subjects.
ISSN:0306-5251
1365-2125
DOI:10.1111/j.1365-2125.2005.02541.x