Refined genetic mapping of X-linked Charcot-Marie-Tooth neuropathy

Genetic linkage studies were conducted in four multigenerational families with X-linked Charcot-Marie-Tooth disease (CMTX), using 12 highly polymorphic short-tandem-repeat markers for the pericentromeric region of the X chromosome. Pairwise linkage analysis with individual markers confirmed tight li...

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Bibliographic Details
Published in:American journal of human genetics 1994-02, Vol.54 (2), p.229-235
Main Authors: FAIN, P. R, BARKER, D. F, CHANCE, P. F
Format: Article
Language:English
Subjects:
Adult
BASIC BIOLOGICAL SCIENCES
Biological and medical sciences
Charcot-Marie-Tooth disease
Charcot-Marie-Tooth Disease - genetics
Chromosome Mapping
CHROMOSOMES
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
DISEASES
Female
Genetic Linkage
GENETIC MAPPING
Genetic Markers
Haplotypes
HETEROCHROMOSOMES
HUMAN CHROMOSOMES
HUMAN X CHROMOSOME
Humans
linkage analysis
Male
man
MAPPING
Medical sciences
NERVOUS SYSTEM DISEASES
Neurology
Pedigree
Recombination, Genetic
X Chromosome
X CHROMOSOME 550400 > Genetics
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Summary:Genetic linkage studies were conducted in four multigenerational families with X-linked Charcot-Marie-Tooth disease (CMTX), using 12 highly polymorphic short-tandem-repeat markers for the pericentromeric region of the X chromosome. Pairwise linkage analysis with individual markers confirmed tight linkage of CMTX to the pericentromeric region in each family. Multipoint analyses strongly support the order DXS337-CMTX-DXS441-(DXS56,PGK1).
ISSN:0002-9297
1537-6605