Development of Rabies Inhibiting Substance in Skunks Infected with Rabies Virus

A study was designed to ascertain the time when rabies inhibiting substance (RIS) developed in relation to the clinical course of rabies in 16 skunks, the relationship of RIS to serum neutralization (SN) antibody, and the effect of RIS on the amount of virus that could be recovered from certain tiss...

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Bibliographic Details
Published in:Public health reports (1896) 1966-10, Vol.81 (10), p.941-944
Main Authors: Parker, R. L., R. K. Sikes
Format: Article
Language:English
Subjects:
Animals
Antibodies
Antibody Formation
Carnivora
Foxes
Inoculation
Rabies
Rabies - immunology
Rabies Vaccines
Rabies virus
Rabies virus - drug effects
Saliva
Salivary gland diseases
Salivary glands
Titration
Viruses
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Summary:A study was designed to ascertain the time when rabies inhibiting substance (RIS) developed in relation to the clinical course of rabies in 16 skunks, the relationship of RIS to serum neutralization (SN) antibody, and the effect of RIS on the amount of virus that could be recovered from certain tissues. Saliva samples collected from three skunks during the clinical course of the disease contained appreciable amounts of rabies virus; however, at necropsy virus could not be isolated from the salivary glands of two of these animals and only a trace was isolated from the salivary gland of the third. SN antibodies were demonstrated in all the skunks in which RIS was demonstrated, confirming an earlier observation. Therefore, a relationship apparently exists between the presence of RIS in tissues and SN antibody. Less virus was recovered when SN antibody was present, and even less virus was present when both RIS and SN antibodies were present. This may result in failure to isolate rabies virus by mouse inoculation, although fluorescent antibody staining reveals the presence of rabies antigen in the tissues. Since RIS seems to develop late in the clinical course of the disease, it is possible that an animal might be capable of transmitting the virus during the furious stage of the disease even though virus could not be isolated from tissues after death.
ISSN:0094-6214
DOI:10.2307/4592875