Prazosin inhibits small intestinal transit in the rat

Gastric emptying, small intestinal transit, and colonic transit were measured in fasted rats preimplanted with either duodenal or colonic cannulae. At the doses stated, prazosin (given subcutaneously) had no effect on gastric emptying or colonic transit, whereas small intestinal transit was signific...

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Bibliographic Details
Published in:British journal of pharmacology 1984-07, Vol.82 (3), p.547-548
Main Authors: Rush, B.D., Ruwart, M.J.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Colon - physiology
Digestive system
Gastric Emptying - drug effects
Gastrointestinal Motility - drug effects
Intestine, Small - physiology
Male
Medical sciences
Pharmacology. Drug treatments
Prazosin - pharmacology
Quinazolines - pharmacology
Rats
Rats, Inbred Strains
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Summary:Gastric emptying, small intestinal transit, and colonic transit were measured in fasted rats preimplanted with either duodenal or colonic cannulae. At the doses stated, prazosin (given subcutaneously) had no effect on gastric emptying or colonic transit, whereas small intestinal transit was significantly delayed.
ISSN:0007-1188
1476-5381
DOI:10.1111/j.1476-5381.1984.tb10792.x