Acute intermittent porphyria and phaeochromocytoma: shared features

[...]few clinicians gain experience in recognising the spectrum of their clinical presentation. [...]the evidence base is limited to reports on small numbers of patients, relying on assay methodology which is no longer in clinical use. 5- 7 More recently, there has been one report of diagnostic conf...

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Bibliographic Details
Published in:Journal of clinical pathology 2007-08, Vol.60 (8), p.935-936
Main Authors: Stewart, M F, Croft, J, Reed, P, New, J P
Format: Article
Language:English
Subjects:
Abdomen
acute intermittent porphyria
Adrenal Gland Neoplasms - diagnosis
Adrenal glands
Adult
Biological and medical sciences
Cardiac arrhythmia
Case Reports
Catecholamines - urine
Chromatography
Diagnosis, Differential
Errors of metabolism
Female
Humans
Hyperactivity
Hypertension
Hypertension - complications
Investigative techniques, diagnostic techniques (general aspects)
Localization
Medical sciences
Metabolic diseases
Metabolic disorders
Metabolites
Pain
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
phaeochromocytoma
Pheochromocytoma - diagnosis
Porphyria, Acute Intermittent - complications
Porphyria, Acute Intermittent - diagnosis
Porphyria, Acute Intermittent - urine
Proteins and glycoproteins
Urine
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Summary:[...]few clinicians gain experience in recognising the spectrum of their clinical presentation. [...]the evidence base is limited to reports on small numbers of patients, relying on assay methodology which is no longer in clinical use. 5- 7 More recently, there has been one report of diagnostic confusion between the clinical features of phaeochromocytoma and AIP, 8 and a further single case report documenting markedly raised urinary free catecholamines, metadrenalines and vanillylmandelic acid during one of two acute attacks of AIP complicated by severe hypertension. 9 Estimates of the performance of any diagnostic test are dependent on the patient population to which it is applied and the criteria chosen for positive or negative results.
ISSN:0021-9746
1472-4146
DOI:10.1136/jcp.2005.032722