CD5-positive diffuse large B cell lymphoma arising from a CD5-positive follicular lymphoma

Follicular lymphoma (FL) is a neoplasm originating from germinal centre cells, corresponding to 25–40% of non-Hodgkin’s lymphomas. Transformation into diffuse large B cell lymphoma (DLBCL) occurs in about one-third of cases. CD5 is expressed in B-chronic lymphoid leukaemia/small lymphocytic lymphoma...

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Bibliographic Details
Published in:Journal of clinical pathology 2007-05, Vol.60 (5), p.573-575
Main Authors: Vassallo, José, Bousquet, Marina, Quelen, Cathy, Al Saati, Talal, Delsol, Georges, Brousset, Pierre
Format: Article
Language:English
Subjects:
Adult
Antigens, Neoplasm - metabolism
Biological and medical sciences
CD5 Antigens - metabolism
diffuse large B cell lymphoma
Disease Progression
DLBCL
Female
follicular lymphoma
Hematologic and hematopoietic diseases
Humans
Investigative techniques, diagnostic techniques (general aspects)
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Lymphoma, B-Cell - immunology
Lymphoma, B-Cell - pathology
Lymphoma, Follicular - immunology
Lymphoma, Follicular - pathology
Lymphoma, Large B-Cell, Diffuse - immunology
Lymphoma, Large B-Cell, Diffuse - pathology
Medical sciences
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Short Reports
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Description
Summary:Follicular lymphoma (FL) is a neoplasm originating from germinal centre cells, corresponding to 25–40% of non-Hodgkin’s lymphomas. Transformation into diffuse large B cell lymphoma (DLBCL) occurs in about one-third of cases. CD5 is expressed in B-chronic lymphoid leukaemia/small lymphocytic lymphoma and mantle cell lymphoma, but can rarely be expressed in conjunction with CD10 in well-documented cases of FL. In this report one case of grade 1 FL is described, which transformed into a DLBCL 6 months after initial diagnosis, with both tumours expressing CD5. In both specimens, neoplastic cells were strongly positive for CD20, CD79a, bcl-2, bcl-6 and CD5 in virtually all cells. CD10 was strongly positive in initial specimens and weakly positive in the DLBCL. Investigation using the PCR confirmed the derivation of the DLBCL from the FL as they presented the same immunoglobulin heavy chain gene rearrangement and the same BCL2-JH break point.
ISSN:0021-9746
1472-4146
DOI:10.1136/jcp.2005.032896