Procalcitonin does discriminate between sepsis and systemic inflammatory response syndrome

Aims: To evaluate whether procalcitonin (PCT) and C reactive protein (CRP) are able to discriminate between sepsis and systemic inflammatory response syndrome (SIRS) in critically ill children. Methods: Prospective, observational study in a paediatric intensive care unit. Kinetics of PCT and CRP wer...

Full description

Saved in:
Bibliographic Details
Published in:Archives of disease in childhood 2006-02, Vol.91 (2), p.117-120
Main Authors: Arkader, R, Troster, E J, Lopes, M R, Júnior, R R, Carcillo, J A, Leone, C, Okay, T S
Format: Article
Language:English
Subjects:
Adolescent
Analysis
Antibiotics
Antibodies
Bacterial Infections - diagnosis
Biological and medical sciences
Biomarkers - blood
C reactive protein
C reactive protein (CRP)
C-Reactive Protein - analysis
C-Reactive Protein - metabolism
Calcitonin
Calcitonin - blood
Calcitonin Gene-Related Peptide
Cardiopulmonary Bypass
cardiopulmonary bypass (CPB)
Cerebrospinal fluid
Child
Child, Preschool
Children
CPB
CRP
Diagnosis
Diagnosis, Differential
Diseases
E coli
Female
General aspects
Heart Defects, Congenital - surgery
Heart surgery
Humans
Infant
Infant, Newborn
Infections
Male
Medical sciences
Neonates
Observational studies
Original
Patients
PCT
Pediatric diseases
Pediatrics
POD
post-operation day
Postoperative Complications - diagnosis
procalcitonin
procalcitonin (PCT)
Prospective Studies
Protein Precursors - blood
Sampling
Sepsis
Sepsis - diagnosis
SIRS
Statistical Analysis
Statistical Significance
Surgery
systemic inflammatory response syndrome
systemic inflammatory response syndrome (SIRS)
Systemic Inflammatory Response Syndrome - diagnosis
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Aims: To evaluate whether procalcitonin (PCT) and C reactive protein (CRP) are able to discriminate between sepsis and systemic inflammatory response syndrome (SIRS) in critically ill children. Methods: Prospective, observational study in a paediatric intensive care unit. Kinetics of PCT and CRP were studied in patients undergoing open heart surgery with cardiopulmonary bypass (CPB) (SIRS model; group I1) and patients with confirmed bacterial sepsis (group II). Results: In group I, PCT median concentration was 0.24 ng/ml (reference value 2 ng/ml for PCT and >79 mg/l for CRP. Conclusion: PCT is able to differentiate between SIRS and sepsis while CRP is not. Moreover, unlike CRP, PCT concentrations varied with the evolution of sepsis.
ISSN:0003-9888
1468-2044
DOI:10.1136/adc.2005.077446