The response of mammalian cells to double-stranded RNA

Abstract Double-stranded RNA (dsRNA) has long been recognized as a central component of the interferon (IFN) system. It was originally characterized as a key mediator of IFN induction in response to virus infection. Subsequently, it was identified as a prime activator of the antiviral response. In r...

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Bibliographic Details
Published in:Cytokine & growth factor reviews 2007-10, Vol.18 (5), p.363-371
Main Authors: Gantier, Michael P, Williams, Bryan R.G
Format: Article
Language:English
Subjects:
Advanced Basic Science
Animals
Double-stranded RNA
Humans
Immunity, Innate
Innate immunity
RNA interference
RNA Interference - immunology
RNA, Double-Stranded - immunology
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Summary:Abstract Double-stranded RNA (dsRNA) has long been recognized as a central component of the interferon (IFN) system. It was originally characterized as a key mediator of IFN induction in response to virus infection. Subsequently, it was identified as a prime activator of the antiviral response. In recent years the discovery of the RNA interference (RNAi) pathway in mammals has renewed interest in dsRNA-mediated cellular responses. This has coincided with the identification of key components of the IFN induction pathway. Here, we present an overview of the current knowledge of dsRNA-mediated pathways in mammalian cells and introduce a link between these pathways and application of RNAi.
ISSN:1359-6101
DOI:10.1016/j.cytogfr.2007.06.016