Stress history and breast cancer recurrence

Abstract Background There is mixed evidence regarding the possible association between a history of stressful or traumatic life events and more rapid breast cancer progression. Method Retrospective reports of past experiences of traumatic life events were assessed among 94 women with metastatic or r...

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Bibliographic Details
Published in:Journal of psychosomatic research 2007-09, Vol.63 (3), p.233-239
Main Authors: Palesh, Oxana, Butler, Lisa D, Koopman, Cheryl, Giese-Davis, Janine, Carlson, Robert, Spiegel, David
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Arousal - physiology
Breast cancer
Breast Neoplasms - mortality
Breast Neoplasms - pathology
Breast Neoplasms - psychology
Disease Progression
Disease-free interval
Disease-Free Survival
Female
Follow-Up Studies
Humans
Hydrocortisone - blood
Hypothalamic-pituitary-adrenal axis
Hypothalamo-Hypophyseal System - physiopathology
Life Change Events
Metastatic breast cancer
Middle Aged
Neoplasm Metastasis
Neoplasm Recurrence, Local - mortality
Neoplasm Recurrence, Local - pathology
Neoplasm Recurrence, Local - psychology
Neoplasm Staging
Pituitary-Adrenal System - physiopathology
Prognosis
Psychiatry
Recurrence
Risk Factors
Stressful events
Traumatic events
Traumatic life events
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Summary:Abstract Background There is mixed evidence regarding the possible association between a history of stressful or traumatic life events and more rapid breast cancer progression. Method Retrospective reports of past experiences of traumatic life events were assessed among 94 women with metastatic or recurrent breast cancer. A traumatic event assessment was conducted using the event-screening question from the posttraumatic stress disorder (PTSD) module of the Structured Clinical Interview for the DSM-IV-TR (SCID; 2002). Each reported event was judged by two independent raters to determine whether it met DSM-IV-TR PTSD A1 criteria for a traumatic event. Those events that did not meet such criteria were designated “stressful events.” Results Nearly 42% of the women in the sample were judged to have experienced one or more traumatic events; 28.7% reported only stressful events. A Kruskal–Wallis test found significant differences in disease-free interval among the three groups [ χ2 (2, N =94)=6.09, P
ISSN:0022-3999
1879-1360
DOI:10.1016/j.jpsychores.2007.05.012