Electron Microscope Observations on Tingible Body Macrophages in Mouse Spleen

It is generally accepted that the tingible bodies (Körper) of Flemming found in lymphatic tissue germinal centers represent phagocytized nuclear debris of small lymphocytes and others) or both lymphocyte and erythrocyte debris. Several ideas about the significance of tingible bodies assume that they...

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Bibliographic Details
Published in:The Journal of cell biology 1963-12, Vol.19 (3), p.641-646
Main Authors: Swartzendruber, D. C., Congdon, C. C.
Format: Article
Language:English
Subjects:
Animals
Antigens
BASIC BIOLOGICAL SCIENCES
Biophysics
Bone marrow cells
Brief Notes
Coloring Agents
Electron microscopy
Electrons
Lymphocytes
Lymphoid tissue
Macrophages
Mice
Microscopy
Microscopy, Electron
Old Medline
Phagocytes
Phagocytosis
Plasma cells
Spleen
Staining and Labeling
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Summary:It is generally accepted that the tingible bodies (Körper) of Flemming found in lymphatic tissue germinal centers represent phagocytized nuclear debris of small lymphocytes and others) or both lymphocyte and erythrocyte debris. Several ideas about the significance of tingible bodies assume that they are small lymphocytes. The "graveyard theory" emphasizes the phagocytosis of pyknotic small lymphocytes. This theory was extended by Hamilton, Trowell, and Sundberg who postulated reutilization of small lymphocytes in lymphocytopoiesis. Andrew stressed the role of degeneration and phagocytosis of small lymphocytes in germinal centers as indicating that these centers are not germinal but reactive, as proposed by Hellman. Recently, Ortega and Mellors suggested that intrinsic germinal center cells degenerated after secreting gamma globulin and were phagocytized by tingible body macrophages.
ISSN:0021-9525
1540-8140
DOI:10.1083/jcb.19.3.641