Iontophoretic Release of Cyclic AMP and Dispersion of Melanosomes within a Single Melanophore

Selective dispersion of melanosomes was often observed after iontophoretic injection of cyclic adenosine monophosphate (AMP) from a glass microelectrode positioned in a target melanophore in frog skin (as viewed from above through a microscope), with other melanophores in the field serving as contro...

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Bibliographic Details
Published in:The Journal of cell biology 1977-09, Vol.74 (3), p.928-939
Main Authors: Geschwind, Irving I., Horowitz, John M., Mikuckis, Gene M., Dewey, Robert D.
Format: Article
Language:English
Subjects:
Animals
Anura
Cell membranes
Cells
Cyclic AMP - pharmacology
Cyclic GMP - pharmacology
Electrodes
Hormones
Melanins
Melanophores
Melanophores - drug effects
Melanophores - physiology
Melanophores - ultrastructure
Melanosomes
Membrane potential
Membrane Potentials
Models, Biological
Neurons
Organoids - drug effects
Rana pipiens
Receptors
Skin
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Description
Summary:Selective dispersion of melanosomes was often observed after iontophoretic injection of cyclic adenosine monophosphate (AMP) from a glass microelectrode positioned in a target melanophore in frog skin (as viewed from above through a microscope), with other melanophores in the field serving as controls. Because the skin has orderly arrays of several types of closely spaced cells, it is probable that at times the microelectrode also impales cells other than melanophores. When cyclic AMP injection inside a cell resulted in dispersion of melanosomes from a perinuclear position into dendritic processes, the onset of dispersion was relatively rapid, in many cases
ISSN:0021-9525
1540-8140
DOI:10.1083/jcb.74.3.928