Relapsing encephalopathy with headache: an unusual presentation of isolated intracranial neurosarcoidosis

After cranial neuropathy, headache is the most common manifestation of neurosarcoidosis, affecting an estimated 30% of patients. 2 There is no typical headache although reports suggest leptomeningeal inflammation is often associated with diffuse or bifrontal pain, and may be associated with papilloe...

Full description

Saved in:
Bibliographic Details
Published in:Journal of neurology, neurosurgery and psychiatry neurosurgery and psychiatry, 2007-07, Vol.78 (7), p.770-771
Main Authors: Rudkin, Adam K, Wilcox, Robert A, Slee, Mark, Kupa, Anne, Thyagarajan, Dominic
Format: Article
Language:English
Subjects:
Adult
Biopsy
Brain Diseases - complications
Brain Diseases - diagnosis
Diagnosis, Differential
Female
Headache - etiology
Headaches
Humans
Inflammation
Letters
NMR
Nuclear magnetic resonance
Periodicity
Proteins
Psychosis
Psychotic Disorders - diagnosis
Recurrence
Sarcoidosis
Sarcoidosis - complications
Sarcoidosis - diagnosis
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:After cranial neuropathy, headache is the most common manifestation of neurosarcoidosis, affecting an estimated 30% of patients. 2 There is no typical headache although reports suggest leptomeningeal inflammation is often associated with diffuse or bifrontal pain, and may be associated with papilloedema, as noted in this case. 3 CSF analysis can be helpful when a pattern of mild pleocytosis, high protein content and, sometimes, reduced glucose is seen. [...]CSF abnormalities are not specific to the disease, may be evanescent and in more than a third of cases patients have a normal CSF. 1 Cranial MRI is the most valuable investigative tool with CNS lesions present in 80-90% of affected patients. 4 In our case the MRI findings suggestive of leptomeningeal inflammation were made 3 years after the first admission, following previously normal cranial magnetic resonance imaging studies.
ISSN:0022-3050
1468-330X
DOI:10.1136/jnnp.2006.104703