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Satellite Cell Proliferation in the Adult Rat Trigeminal Ganglion Results from the Release of a Mitogenic Protein from Explanted Sensory Neurons

Explant of trigeminal ganglia neurons in adult rats induces perineuronal glial proliferation of primarily satellite cells as opposed to Schwann cells. This proliferation begins at 15 h after explant culture and by 27 h there is a significant increase in glial proliferation as measured by scintillati...

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Published in:	The Journal of cell biology 1994-03, Vol.124 (6), p.1005-1015
Main Authors:	Joseph Y. M. Wen, Morshead, Cindi M., van der Kooy, Derek
Format:	Article
Language:	English
Subjects:	Animals Artificial satellites Biological and medical sciences Cell cycle, cell proliferation Cell Division Cell growth Cell physiology Cellular biology Culture Media, Conditioned Culture Techniques Cultured cells Cycloheximide - pharmacology Fundamental and applied biological sciences. Psychology Ganglia Hot Temperature Male Mitogens Mitogens - metabolism Molecular and cellular biology Nerve Growth Factors - pharmacology Nerve Tissue Proteins - pharmacology Neuroglia Neuroglia - cytology Neurons Neurons, Afferent - metabolism Neurons, Afferent - physiology Protein Biosynthesis Protein synthesis Rats Rodents S Phase Schwann cells Trigeminal ganglion Trigeminal Ganglion - cytology
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container_issue	6
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container_title	The Journal of cell biology
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creator	Joseph Y. M. Wen Morshead, Cindi M. van der Kooy, Derek
description	Explant of trigeminal ganglia neurons in adult rats induces perineuronal glial proliferation of primarily satellite cells as opposed to Schwann cells. This proliferation begins at 15 h after explant culture and by 27 h there is a significant increase in glial proliferation as measured by scintillation counts of [3H]thymidine. Blocking protein synthesis between 0 and 3.5 h after explant culture (early) results in an enhanced proliferative response, while blocking protein synthesis between 3.5 and 7 h (late) causes a complete block of the proliferative response assessed at 27 h. Conditioned media experiments demonstrate that both the mitogenic and inhibitory signals are diffusible and heat labile. Finally, the addition of neurotrophic factors to rescue injured ganglionic neurons attenuates the proliferative glial response suggesting that injured neurons produce and release signals that induce glial proliferation.
doi_str_mv	10.1083/jcb.124.6.1005
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M. Wen</creatorcontrib><creatorcontrib>Morshead, Cindi M.</creatorcontrib><creatorcontrib>van der Kooy, Derek</creatorcontrib><title>Satellite Cell Proliferation in the Adult Rat Trigeminal Ganglion Results from the Release of a Mitogenic Protein from Explanted Sensory Neurons</title><title>The Journal of cell biology</title><addtitle>J Cell Biol</addtitle><description>Explant of trigeminal ganglia neurons in adult rats induces perineuronal glial proliferation of primarily satellite cells as opposed to Schwann cells. This proliferation begins at 15 h after explant culture and by 27 h there is a significant increase in glial proliferation as measured by scintillation counts of [3H]thymidine. Blocking protein synthesis between 0 and 3.5 h after explant culture (early) results in an enhanced proliferative response, while blocking protein synthesis between 3.5 and 7 h (late) causes a complete block of the proliferative response assessed at 27 h. 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Psychology</subject><subject>Ganglia</subject><subject>Hot Temperature</subject><subject>Male</subject><subject>Mitogens</subject><subject>Mitogens - metabolism</subject><subject>Molecular and cellular biology</subject><subject>Nerve Growth Factors - pharmacology</subject><subject>Nerve Tissue Proteins - pharmacology</subject><subject>Neuroglia</subject><subject>Neuroglia - cytology</subject><subject>Neurons</subject><subject>Neurons, Afferent - metabolism</subject><subject>Neurons, Afferent - physiology</subject><subject>Protein Biosynthesis</subject><subject>Protein synthesis</subject><subject>Rats</subject><subject>Rodents</subject><subject>S Phase</subject><subject>Schwann cells</subject><subject>Trigeminal ganglion</subject><subject>Trigeminal Ganglion - cytology</subject><issn>0021-9525</issn><issn>1540-8140</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><recordid>eNqFkktvGyEUhVHVKnXcbrtqJVRF3dmFYYZhNpUiK00rpQ856RoxzMXBwuAAUzX_oj-5OLbcx6ZicYXOx7lwOQi9oGROiWBv17qf06qe87IlzSM0oU1NZoLW5DGaEFLRWddUzVN0mtKaEFK3NTtBJ4KyqiX1BP28VhmcsxnwolT8NQZnDUSVbfDYepxvAZ8Po8t4qTK-iXYFG-uVw5fKr9wOWkIqcsImhs0DvgQHKgEOBiv8yeawAm_1zjpDcXzgLn5snfIZBnwNPoV4jz_DGINPz9ATo1yC54c6Rd_eX9wsPsyuvlx-XJxfzXTdsTxjmirgVOha93roG6No33R9T3gtGkYNNb3gnHSUNwqGoWpo07daGEYodAYEm6J3e9_t2G9g0OBzVE5uo92oeC-DsvJvxdtbuQrfZUVp15UpTtGbg0EMdyOkLDc26TJD5SGMSbacdeUb2v-ClIsCElrA1_-A6zDGMutUmrakE0xUBZrvIR1DShHM8cqUyF0iZEmELImQXO4SUQ68-vOhR_wQgaKfHXSVtHImKq9tOmI1JRVvu4K93GPrlEP83ZSXRRj7BelRyoU</recordid><startdate>19940301</startdate><enddate>19940301</enddate><creator>Joseph Y. M. Wen</creator><creator>Morshead, Cindi M.</creator><creator>van der Kooy, Derek</creator><general>Rockefeller University Press</general><general>The Rockefeller University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19940301</creationdate><title>Satellite Cell Proliferation in the Adult Rat Trigeminal Ganglion Results from the Release of a Mitogenic Protein from Explanted Sensory Neurons</title><author>Joseph Y. M. 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subjects	Animals Artificial satellites Biological and medical sciences Cell cycle, cell proliferation Cell Division Cell growth Cell physiology Cellular biology Culture Media, Conditioned Culture Techniques Cultured cells Cycloheximide - pharmacology Fundamental and applied biological sciences. Psychology Ganglia Hot Temperature Male Mitogens Mitogens - metabolism Molecular and cellular biology Nerve Growth Factors - pharmacology Nerve Tissue Proteins - pharmacology Neuroglia Neuroglia - cytology Neurons Neurons, Afferent - metabolism Neurons, Afferent - physiology Protein Biosynthesis Protein synthesis Rats Rodents S Phase Schwann cells Trigeminal ganglion Trigeminal Ganglion - cytology
title	Satellite Cell Proliferation in the Adult Rat Trigeminal Ganglion Results from the Release of a Mitogenic Protein from Explanted Sensory Neurons
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