Association of mutations in mannose binding protein gene with childhood infection in consecutive hospital series

Abstract Objective: To determine the extent to which mutations in the mannose binding protein gene predispose to childhood infection. Design: Clinical details and genotype of mannose binding protein determined in consecutive children attending a paediatric department. Setting: Inner city hospital pa...

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Bibliographic Details
Published in:BMJ 1997-04, Vol.314 (7089), p.1229-1232
Main Authors: Summerfield, John A, Sumiya, Michiko, Levin, Michael, Turner, Malcolm W
Format: Article
Language:English
Subjects:
Adolescent
Age Factors
Alleles
Biological and medical sciences
Carrier proteins
Carrier Proteins - genetics
Child
Child health services
Child, Preschool
Childhood
Children
Children & youth
Codons
Disease Susceptibility
Female
General aspects
Genes
Genetic mutation
Genotypes
Health risk assessment
Heterozygote
Homozygote
Hospitalization
Humans
Infant
Infant, Newborn
Infection - genetics
Infection pathogenesis
Infections
Infectious diseases
Male
Mannose
Mannose-Binding Lectins
Medical sciences
Mutation
Pediatrics
Proteins
Risk Factors
Citations: Items that cite this one
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Summary:Abstract Objective: To determine the extent to which mutations in the mannose binding protein gene predispose to childhood infection. Design: Clinical details and genotype of mannose binding protein determined in consecutive children attending a paediatric department. Setting: Inner city hospital paediatric service in London. Subjects: 617 children attending hospital between October 1993 and August 1995. Main outcome measure: Infection as the cause for attendance or admission in relation to mutations in the mannose binding protein gene. Results: The prevalence of mutations in the mannose binding protein gene in children with infection (146/345) was about twice that in children without infection (64/272) (P
ISSN:0959-8138
0959-8146
1468-5833
1756-1833
DOI:10.1136/bmj.314.7089.1229