Structure and function of the bacterial mechanosensitive channel of large conductance

Mechanosensation in bacteria involves transducing membrane stress into an electrochemical response. In Escherichia coli and other bacteria, this function is carried out by a number of proteins including MscL, the mechanosensitive channel of large conductance. MscL is the best characterized of all me...

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Bibliographic Details
Published in:Protein science 1999-10, Vol.8 (10), p.1915-1921
Main Authors: OAKLEY, AARON J., MARTINAC, BORIS, WILCE, MATTHEW C.J.
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Bacterial Proteins - chemistry
Bacterial Proteins - metabolism
Escherichia coli Proteins
ion channel
Ion Channel Gating
Ion Channels - chemistry
Ion Channels - metabolism
mechanosensation
mechanosensitive channel of large conductance
membrane protein
Models, Molecular
Molecular Sequence Data
Mycobacterium tuberculosis - chemistry
Protein Conformation
REVIEW
Sequence Homology, Amino Acid
Space life sciences
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Summary:Mechanosensation in bacteria involves transducing membrane stress into an electrochemical response. In Escherichia coli and other bacteria, this function is carried out by a number of proteins including MscL, the mechanosensitive channel of large conductance. MscL is the best characterized of all mechanosensitive channels. It has been the subject of numerous structural and functional investigations. The explosion in experimental data on MscL recently culminated in the solution of the three-dimensional structure of the MscL homologue from Mycobacterium tuberculosis. In this review, much of these data are united and interpreted in terms of the newly published M. tuberculosis MscL crystal structure.
ISSN:0961-8368
1469-896X
DOI:10.1110/ps.8.10.1915