Dopaminergic deficit in amyotrophic lateral sclerosis assessed with [I-123] IPT single photon emission computed tomography

• Published in: Journal of neurology, neurosurgery and psychiatry neurosurgery and psychiatry, 1998-08, Vol.65 (2), p.263-265
• Main Authors: Borasio, G D, Linke, R, Schwarz, J, Schlamp, V, Abel, A, Mozley, P D, Tatsch, K
• Format: Article
• Language: English
• Subjects: Adult; Age; Aged; Aged, 80 and over; Amyotrophic lateral sclerosis; Amyotrophic Lateral Sclerosis - diagnostic imaging; Amyotrophic Lateral Sclerosis - physiopathology; basal ganglia; Basal Ganglia - diagnostic imaging; Biological and medical sciences; Carrier Proteins - physiology; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Dementia; Dopamine; Dopamine - physiology; Dopamine Plasma Membrane Transport Proteins; dopamine transporter; Female; Humans; Image Processing, Computer-Assisted; Iodine Radioisotopes; Male; Medical sciences; Membrane Glycoproteins; Membrane Transport Proteins; Middle Aged; motor neuron disease; Nerve Tissue Proteins; Neurology; Neurons; Neuropathology; Parkinson's disease; Patients; Reference Values; Short Report; single photon emission tomography; Tomography; Tomography, Emission-Computed, Single-Photon; Tropanes
• ISSN: 0022-3050; 1468-330X
• DOI: 10.1136/jnnp.65.2.263

Dopamine transporter imaging was performed in 18 patients with sporadic amyotrophic lateral sclerosis (ALS) and 11 age matched controls with [I-123] IPT (N-(3-iodopropen-2-yl)-2β-carbomethoxy-3β(4-chlorophenyl)-tropane), a new cocaine analogue that selectively binds to the dopamine transporter located on dopaminergic nerve terminals. Image analysis showed that striatal IPT binding was moderately but significantly reduced in the ALS group compared with controls (p