Evidence against C‐type natriuretic peptide as an arterial ‘EDHF’

C‐type natriuretic peptide (CNP) is found in and released from vascular endothelial cells. Recently, a novel role has been suggested for this peptide, that of an endothelium‐derived hyperpolarizing factor or EDHF. Implicit in this proposal is a widespread role for CNP as a key mediator of vascular d...

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Bibliographic Details
Published in:British journal of pharmacology 2008-01, Vol.153 (1), p.4-5
Main Authors: Garland, C J, Dora, K A
Format: Article
Language:English
Subjects:
acetylcholine
Acetylcholine - pharmacology
Animals
Biological Factors - physiology
Carotid Arteries - drug effects
Carotid Arteries - physiology
Commentaries
C‐type natriuretic peptide
EDHF
endothelium
gap‐junctions
Humans
hyperpolarization
Membrane Potentials - drug effects
Natriuretic Peptide, C-Type - pharmacology
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Summary:C‐type natriuretic peptide (CNP) is found in and released from vascular endothelial cells. Recently, a novel role has been suggested for this peptide, that of an endothelium‐derived hyperpolarizing factor or EDHF. Implicit in this proposal is a widespread role for CNP as a key mediator of vascular dilatation. In this issue of the British Journal of Pharmacology, Leuranguer et al. compare the profile of membrane potential changes evoked with this putative EDHF or with endogenous EDHF (activated with ACh) in small carotid arteries. Marked differences between the two profiles lead them to discount a possible role for CNP as an EDHF. British Journal of Pharmacology (2008) 153, 4–5; doi:10.1038/sj.bjp.0707520; published online 29 October 2007
ISSN:0007-1188
1476-5381
DOI:10.1038/sj.bjp.0707520