Reduced risk of synovial sarcoma in females: X-chromosome inactivation?

Synovial sarcoma shows a characteristic t(X;18) translocation but not the expected female predominance in incidence. We speculate that, among females, one X-chromosome is inactivated and that only the translocation to an active X-chromosome leads to development of synovial sarcoma. Population-based...

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Bibliographic Details
Published in:British journal of cancer 2002-07, Vol.87 (1), p.28-30
Main Authors: Bu, X, Bernstein, L, Brynes, R K
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age groups
Aged
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Cancer Research
Child
Child, Preschool
Diseases of the osteoarticular system
Drug Resistance
Epidemiology
Female
Females
Genes
Genetic Predisposition to Disease
Humans
Hypotheses
Incidence
Infant
Infant, Newborn
Male
Males
Medical research
Medical sciences
Medicine
Middle Aged
Molecular Medicine
Oncology
Sarcoma
Sarcoma, Synovial - epidemiology
Sarcoma, Synovial - etiology
Sarcoma, Synovial - genetics
SEER Program
Soft Tissue Neoplasms - epidemiology
Soft Tissue Neoplasms - etiology
Soft Tissue Neoplasms - genetics
Surveillance
Translocation, Genetic
Tumors of striated muscle and skeleton
X Chromosome - genetics
X chromosomes
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Description
Summary:Synovial sarcoma shows a characteristic t(X;18) translocation but not the expected female predominance in incidence. We speculate that, among females, one X-chromosome is inactivated and that only the translocation to an active X-chromosome leads to development of synovial sarcoma. Population-based cancer registry data from the SEER program support this hypothesis.
ISSN:0007-0920
1532-1827
DOI:10.1038/sj.bjc.6600362