A role for sex chromosome complement in the female bias in autoimmune disease

Most autoimmune diseases are more common in women than in men. This may be caused by differences in sex hormones, sex chromosomes, or both. In this study, we determined if there was a contribution of sex chromosomes to sex differences in susceptibility to two immunologically distinct disease models,...

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Bibliographic Details
Published in:The Journal of experimental medicine 2008-05, Vol.205 (5), p.1099-1108
Main Authors: Smith-Bouvier, Deborah L, Divekar, Anagha A, Sasidhar, Manda, Du, Sienmi, Tiwari-Woodruff, Seema K, King, Jennifer K, Arnold, Arthur P, Singh, Ram Raj, Voskuhl, Rhonda R
Format: Article
Language:English
Subjects:
Animals
Autoantibodies - blood
Autoimmune Diseases - genetics
Castration
Chromosomes, Human, X
Chromosomes, Human, Y
Complement System Proteins - genetics
Female
Genetic Predisposition to Disease
Humans
Immunization
Male
Mice
Mice, Inbred C57BL
Mice, Inbred Strains
Nephritis - genetics
Nephritis - immunology
Ovariectomy
Sex Chromosomes
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Summary:Most autoimmune diseases are more common in women than in men. This may be caused by differences in sex hormones, sex chromosomes, or both. In this study, we determined if there was a contribution of sex chromosomes to sex differences in susceptibility to two immunologically distinct disease models, experimental autoimmune encephalomyelitis (EAE) and pristane-induced lupus. Transgenic SJL mice were created to permit a comparison between XX and XY within a common gonadal type. Mice of the XX sex chromosome complement, as compared with XY, demonstrated greater susceptibility to both EAE and lupus. This is the first evidence that the XX sex chromosome complement, as compared with XY, confers greater susceptibility to autoimmune disease.
ISSN:0022-1007
1540-9538
1892-1007
DOI:10.1084/jem.20070850