Phenotypic characteristics of colo-rectal cancer in I1307K APC germline mutation carriers compared with sporadic cases

The I1307K APC germline mutation is associated with an increased risk to colo-rectal cancer (CRC). Whether and to what extent the phenotype of CRC in mutation carriers differs from sporadic cases, remains unknown. To gain insight into this issue, we analysed 307 unselected Israeli patients with CRC,...

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Bibliographic Details
Published in:British journal of cancer 2001-11, Vol.85 (9), p.1368-1371
Main Authors: Figer, A, Shtoyerman-Chen, R, Tamir, A, Geva, R, Irmin, L, Flex, D, Theodor, L, Sulkes, A, Sadetzki, S, Bar-Meir, S, Friedman, E
Format: Article
Language:English
Subjects:
Adult
Age of Onset
Aged
Aged, 80 and over
APC gene
Biomedical and Life Sciences
Biomedicine
Cancer Research
Colorectal cancer
Colorectal Neoplasms - genetics
Colorectal Neoplasms - pathology
DNA Mutational Analysis
DNA, Neoplasm
Drug Resistance
Epidemiology
Family medical history
Female
Genes, APC
Germ-Line Mutation - genetics
Humans
Male
Medical research
Middle Aged
Molecular Medicine
Mutation
Neoplasm Staging
Oncology
Pedigree
Phenotype
Polymerase Chain Reaction
Regular
regular-article
Sex Factors
Statistical analysis
Tumors
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Summary:The I1307K APC germline mutation is associated with an increased risk to colo-rectal cancer (CRC). Whether and to what extent the phenotype of CRC in mutation carriers differs from sporadic cases, remains unknown. To gain insight into this issue, we analysed 307 unselected Israeli patients with CRC, who were treated in a single medical centre, for harbouring the I1307K mutation. Twenty-eight mutation carriers (9.1%) were detected. Two of 28 mutation carriers (7.1%) and 93/277 (33.6%) of non-carriers, were of non-Ashkenazi origin ( P < 0.01). In 74/278 (26.6%) of the sporadic cases, and only 1/28 (3.6%) of mutation carriers (3.6%) the tumour was located in the right colon ( P < 0.01). Mutation carriers had a more advanced disease stage (14/28 – 50% Dukes C), as compared with 60 (19.5%) of non-carriers ( P = 0.02). The mean age at diagnosis was similar: 65 (+/– 9.7) years and 66.3 (+/– 11.6) years, for mutation carriers and non-carriers, respectively. No statistical differences were noted between the two groups in sex distribution, tumour grade, and family history of cancer. We conclude that early age at diagnosis and family history of cancer cannot be used to predict who is likely to harbour the I1307K APC germline mutation carriers. However, the tumours in patients with this mutation appear different than those without, are less likely to be proximal and more likely to be advanced than tumours in non-carriers. © 2001 Cancer Research Campaign http://www.bjcancer.com
ISSN:0007-0920
1532-1827
DOI:10.1054/bjoc.2001.2093