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Role for metabotropic glutamate receptor 5 (mGluR5) in the pathogenesis of fragile X syndrome
Metabotropic glutamate receptors (mGluRs) have been implicated in a diverse variety of neuronal functions. Studies reviewed here indicate that exaggerated signalling through mGluR5 can account for multiple cognitive and syndromic features of fragile X syndrome, the most common inherited form of ment...
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| Published in: | The Journal of physiology 2008-03, Vol.586 (6), p.1503-1508 |
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| Main Authors: | , |
| Format: | Article |
| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c5861-304432fb71febc7d4b63bf518d1ef3af185c9c7adbd8d4d09b798f9bc282228d3 |
| container_end_page | 1508 |
| container_issue | 6 |
| container_start_page | 1503 |
| container_title | The Journal of physiology |
| container_volume | 586 |
| creator | Dölen, Gül Bear, Mark F |
| description | Metabotropic glutamate receptors (mGluRs) have been implicated in a diverse variety of neuronal functions. Studies reviewed
here indicate that exaggerated signalling through mGluR5 can account for multiple cognitive and syndromic features of fragile
X syndrome, the most common inherited form of mental retardation and autism. Since a reduction of mGluR5 signalling can reverse
fragile X phenotypes, these studies provide a compelling rationale for the use of mGluR5 antagonists for the treatment of
fragile X and related disorders. |
| doi_str_mv | 10.1113/jphysiol.2008.150722 |
| format | article |
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here indicate that exaggerated signalling through mGluR5 can account for multiple cognitive and syndromic features of fragile
X syndrome, the most common inherited form of mental retardation and autism. Since a reduction of mGluR5 signalling can reverse
fragile X phenotypes, these studies provide a compelling rationale for the use of mGluR5 antagonists for the treatment of
fragile X and related disorders.</description><identifier>ISSN: 0022-3751</identifier><identifier>EISSN: 1469-7793</identifier><identifier>DOI: 10.1113/jphysiol.2008.150722</identifier><identifier>PMID: 18202092</identifier><language>eng</language><publisher>Oxford, UK: The Physiological Society</publisher><subject>Animals ; Brain - metabolism ; Brain - pathology ; Fragile X Syndrome - metabolism ; Fragile X Syndrome - pathology ; Mice ; Mice, Knockout ; Neurons - metabolism ; Neurons - pathology ; Receptor, Metabotropic Glutamate 5 ; Receptors, Metabotropic Glutamate - metabolism ; Symposium Section Reports: New Directions in Synaptic and Network Plasticity</subject><ispartof>The Journal of physiology, 2008-03, Vol.586 (6), p.1503-1508</ispartof><rights>2008 The Authors. Journal compilation © 2008 The Physiological Society</rights><rights>2008 The Authors. Journal compilation © 2008 The Physiological Society 2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5861-304432fb71febc7d4b63bf518d1ef3af185c9c7adbd8d4d09b798f9bc282228d3</citedby><cites>FETCH-LOGICAL-c5861-304432fb71febc7d4b63bf518d1ef3af185c9c7adbd8d4d09b798f9bc282228d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2375688/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2375688/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18202092$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dölen, Gül</creatorcontrib><creatorcontrib>Bear, Mark F</creatorcontrib><title>Role for metabotropic glutamate receptor 5 (mGluR5) in the pathogenesis of fragile X syndrome</title><title>The Journal of physiology</title><addtitle>J Physiol</addtitle><description>Metabotropic glutamate receptors (mGluRs) have been implicated in a diverse variety of neuronal functions. Studies reviewed
here indicate that exaggerated signalling through mGluR5 can account for multiple cognitive and syndromic features of fragile
X syndrome, the most common inherited form of mental retardation and autism. Since a reduction of mGluR5 signalling can reverse
fragile X phenotypes, these studies provide a compelling rationale for the use of mGluR5 antagonists for the treatment of
fragile X and related disorders.</description><subject>Animals</subject><subject>Brain - metabolism</subject><subject>Brain - pathology</subject><subject>Fragile X Syndrome - metabolism</subject><subject>Fragile X Syndrome - pathology</subject><subject>Mice</subject><subject>Mice, Knockout</subject><subject>Neurons - metabolism</subject><subject>Neurons - pathology</subject><subject>Receptor, Metabotropic Glutamate 5</subject><subject>Receptors, Metabotropic Glutamate - metabolism</subject><subject>Symposium Section Reports: New Directions in Synaptic and Network Plasticity</subject><issn>0022-3751</issn><issn>1469-7793</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNqNkU2L1TAUhoMoznX0H4hkJTOLXvPRNslGkMEZlQFlGMGNhDRN2gxtU5PUof_eXHr9Wukqi_O8LyfnAeA5RnuMMX11N_drdH7YE4T4HleIEfIA7HBZi4IxQR-CHUKEFJRV-AQ8ifEOIUyREI_BCeYEESTIDny98YOB1gc4mqQan4KfnYbdsCQ1qmRgMNrMKc8reDZeDctNdQ7dBFNv4KxS7zszmegi9BbaoDqX277AuE5t8KN5Ch5ZNUTz7Piegs-Xb28v3hXXH6_eX7y5LnTFa1xQVJaU2IZhaxrN2rKpaWMrzFtsLFUW80oLzVTbtLwtWyQaJrgVjSacEMJbegpeb73z0oym1WZKQQ1yDm5UYZVeOfn3ZHK97Px3SfJ1as5zwctjQfDfFhOTHF3UZhjUZPwSJUMlIkygf4IElYzl82aw3EAdfIzB2F_bYCQPAuVPgfIgUG4Cc-zFnz_5HToay4DYgPt86vW_SuXth0-EcZyzZ1u2d11_74KRGx29diatMsuQ9SFE6Q8C87tP</recordid><startdate>20080315</startdate><enddate>20080315</enddate><creator>Dölen, Gül</creator><creator>Bear, Mark F</creator><general>The Physiological Society</general><general>Blackwell Publishing Ltd</general><general>Blackwell Science Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20080315</creationdate><title>Role for metabotropic glutamate receptor 5 (mGluR5) in the pathogenesis of fragile X syndrome</title><author>Dölen, Gül ; Bear, Mark F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5861-304432fb71febc7d4b63bf518d1ef3af185c9c7adbd8d4d09b798f9bc282228d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Animals</topic><topic>Brain - metabolism</topic><topic>Brain - pathology</topic><topic>Fragile X Syndrome - metabolism</topic><topic>Fragile X Syndrome - pathology</topic><topic>Mice</topic><topic>Mice, Knockout</topic><topic>Neurons - metabolism</topic><topic>Neurons - pathology</topic><topic>Receptor, Metabotropic Glutamate 5</topic><topic>Receptors, Metabotropic Glutamate - metabolism</topic><topic>Symposium Section Reports: New Directions in Synaptic and Network Plasticity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dölen, Gül</creatorcontrib><creatorcontrib>Bear, Mark F</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dölen, Gül</au><au>Bear, Mark F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role for metabotropic glutamate receptor 5 (mGluR5) in the pathogenesis of fragile X syndrome</atitle><jtitle>The Journal of physiology</jtitle><addtitle>J Physiol</addtitle><date>2008-03-15</date><risdate>2008</risdate><volume>586</volume><issue>6</issue><spage>1503</spage><epage>1508</epage><pages>1503-1508</pages><issn>0022-3751</issn><eissn>1469-7793</eissn><abstract>Metabotropic glutamate receptors (mGluRs) have been implicated in a diverse variety of neuronal functions. Studies reviewed
here indicate that exaggerated signalling through mGluR5 can account for multiple cognitive and syndromic features of fragile
X syndrome, the most common inherited form of mental retardation and autism. Since a reduction of mGluR5 signalling can reverse
fragile X phenotypes, these studies provide a compelling rationale for the use of mGluR5 antagonists for the treatment of
fragile X and related disorders.</abstract><cop>Oxford, UK</cop><pub>The Physiological Society</pub><pmid>18202092</pmid><doi>10.1113/jphysiol.2008.150722</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0022-3751 |
| ispartof | The Journal of physiology, 2008-03, Vol.586 (6), p.1503-1508 |
| issn | 0022-3751 1469-7793 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2375688 |
| source | Wiley-Blackwell Read & Publish Collection; PubMed Central |
| subjects | Animals Brain - metabolism Brain - pathology Fragile X Syndrome - metabolism Fragile X Syndrome - pathology Mice Mice, Knockout Neurons - metabolism Neurons - pathology Receptor, Metabotropic Glutamate 5 Receptors, Metabotropic Glutamate - metabolism Symposium Section Reports: New Directions in Synaptic and Network Plasticity |
| title | Role for metabotropic glutamate receptor 5 (mGluR5) in the pathogenesis of fragile X syndrome |
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