Assessment of regional systolic and diastolic dysfunction in familial hypertrophic cardiomyopathy using MR tagging

Diastolic and systolic left ventricular (LV) dysfunction often significantly contribute to disabling symptoms in familial hypertrophic cardiomyopathy (FHC). This study compares regional LV function (midwall circumferential strain) during systole and diastole in eight FHC patients and six normal volu...

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Bibliographic Details
Published in:Magnetic resonance in medicine 2003-09, Vol.50 (3), p.638-642
Main Authors: Ennis, Daniel B., Epstein, Frederick H., Kellman, Peter, Fananapazir, Lameh, McVeigh, Elliot R., Arai, Andrew E.
Format: Article
Language:English
Subjects:
Biological and medical sciences
cardiomyopathy
Cardiomyopathy, Hypertrophic - physiopathology
diastole
Diastole - physiology
Female
Humans
hypertrophy
Magnetic Resonance Imaging - methods
Male
Medical sciences
Myocardial Contraction - physiology
regional
Systole - physiology
tagging
Ventricular Dysfunction, Left - physiopathology
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Summary:Diastolic and systolic left ventricular (LV) dysfunction often significantly contribute to disabling symptoms in familial hypertrophic cardiomyopathy (FHC). This study compares regional LV function (midwall circumferential strain) during systole and diastole in eight FHC patients and six normal volunteers (NVs) using MR tagging. A prospectively‐gated fast gradient‐echo sequence with an echo‐train readout was modified to support complementary spatial modulation of magnetization (CSPAMM) tagging and full cardiac cycle data acquisition using the cardiac phase to order reconstruction (CAPTOR), thus providing tag persistence and data acquisition during the entire cardiac cycle. Total systolic strains in FHC patients were significantly reduced in septal and inferior regions (both P < 0.01). Early‐diastolic strain rates were reduced in all regions of the FHC group (all P < 0.03). The combination of CSPAMM and CAPTOR allows regional indices of myocardial function to be quantified throughout the cardiac cycle. This technique reveals regional differences in systolic and diastolic impairment in FHC patients. Magn Reson Med 50:638–642, 2003. Published 2003 Wiley‐Liss, Inc.
ISSN:0740-3194
1522-2594
DOI:10.1002/mrm.10543