Cerebellar degeneration following neuroleptic malignant syndrome

A 55-year-old woman with a history of bipolar affective disorder developed hyperpyrexia, rigidity and depressed consciousness (neuroleptic malignant syndrome) after commencing neuroleptic therapy. On regaining consciousness, she was mute and had signs suggesting pancerebellar involvement. Hyperpyrex...

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Bibliographic Details
Published in:Postgraduate medical journal 1997-11, Vol.73 (865), p.735-736
Main Authors: Lal, V., Sardana, V., Thussu, A., Sawhney, I. M., Prabhakar, S.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cerebellar Diseases - etiology
Drug toxicity and drugs side effects treatment
Female
Humans
Medical sciences
Middle Aged
Mutism - etiology
Neuroleptic Malignant Syndrome - complications
Pharmacology. Drug treatments
Toxicity: nervous system and muscle
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Summary:A 55-year-old woman with a history of bipolar affective disorder developed hyperpyrexia, rigidity and depressed consciousness (neuroleptic malignant syndrome) after commencing neuroleptic therapy. On regaining consciousness, she was mute and had signs suggesting pancerebellar involvement. Hyperpyrexia, which is a cardinal feature of neuroleptic malignant syndrome, may have caused cerebellar damage. Neuroleptic malignant syndrome needs both early recognition and prompt treatment to obviate devastating complications.
ISSN:0032-5473
1469-0756
DOI:10.1136/pgmj.73.865.735