Simultaneous administration of smallpox, measles, yellow fever, and diphtheria-pertussis-tetanus antigens to Nigerian children

Children receiving smallpox, measles, and yellow fever vaccines simultaneously at separate sites responded adequately to all three vaccines. In those children, 9 months of age and older, who received these three vaccines in addition to diphtheria-pertussis-tetanus vaccine, there was a decrease in me...

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Bibliographic Details
Published in:Bulletin of the World Health Organization 1973, Vol.48 (2), p.175-181
Main Authors: Ruben, F L, Smith, E A, Foster, S O, Casey, H L, Pifer, J M, Wallace, R B, Atta, A I, Jones, W L, Arnold, R B, Teller, B E, Shaikh, Z Q, Lourie, B, Eddins, D L, Doko, S M, Foege, W H
Format: Article
Language:English
Subjects:
Antibodies, Bacterial - analysis
Antibodies, Viral - analysis
Child, Preschool
Diphtheria - immunology
Diphtheria Toxoid - administration & dosage
Hemagglutination Inhibition Tests
Humans
Infant
Measles - immunology
Measles Vaccine - administration & dosage
Nigeria
Pertussis Vaccine - administration & dosage
Smallpox - immunology
Smallpox Vaccine - administration & dosage
Tetanus - immunology
Tetanus Toxoid - administration & dosage
Time Factors
Vaccination
Viral Vaccines - administration & dosage
Whooping Cough - immunology
Yellow Fever - immunology
Yellow fever virus - immunology
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Summary:Children receiving smallpox, measles, and yellow fever vaccines simultaneously at separate sites responded adequately to all three vaccines. In those children, 9 months of age and older, who received these three vaccines in addition to diphtheria-pertussis-tetanus vaccine, there was a decrease in measles seroconversion rates from 89% to 70%. Possible interactions between live and killed vaccines should be considered when the administration of multiple antigens is planned.
ISSN:0042-9686